You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FEM1B
Protein fem-1 homolog B

Protein Summary
Description
Component of an E3 ubiquitin-protein ligase complex, in which it may act as a substrate recognition subunit. Involved in apoptosis by acting as a death receptor-associated protein that mediates apoptosis. Also involved in glucose homeostasis in pancreatic islet. Functions as an adapter/mediator in replication stress-induced signaling that leads to the activation of CHEK1. This gene encodes an ankyrin repeat protein that belongs to the death receptor-associated family of proteins and plays a role in mediating apoptosis. The encoded protein is also thought to function in the replication stress-induced checkpoint signaling pathway via interaction with checkpoint kinase 1. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000306917
  • ENSP00000307298
  • ENSG00000169018

Symbol
  • F1AA
  • KIAA0396
  • F1AA
  • F1A-ALPHA
  • FEM1-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
kinase perturbation
0.96
virus perturbation
0.96
PubMedID
0.81
gene perturbation
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.05   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 207   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 18.05   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (205)
TRIM44
Tbio
Novelty:  0.00483553
p_int:  0.999996283
p_ni:  0.000003717
Data Source:  BioPlex
GLMN
Tbio
Novelty:  0.01940401
p_int:  0.999978942
p_ni:  0.000021058
Data Source:  BioPlex
SYCE3
Tdark
Novelty:  0.22361224
p_int:  0.999977701
p_ni:  0.000022299
Data Source:  BioPlex
CUL5
Tbio
Novelty:  0.00792494
p_int:  0.999972074
p_ni:  0.000027925
Score:  0.943
Data Source:  BioPlex,STRINGDB
CUL2
Tbio
Novelty:  0.00512916
p_int:  0.999965039
p_ni:  0.000034961
Score:  0.977
Data Source:  BioPlex,STRINGDB
COPS6
Tbio
Novelty:  0.02653008
p_int:  0.999883638
p_ni:  0.000116285
p_wrong:  7.7e-8
Score:  0.978
Data Source:  BioPlex,STRINGDB
SENP5
Tbio
Family:  Enzyme
Novelty:  0.0510532
p_int:  0.999821643
p_ni:  0.000178357
Data Source:  BioPlex
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.99981514
p_ni:  0.000184857
p_wrong:  3e-9
Score:  0.964
Data Source:  BioPlex,STRINGDB
COPS3
Tbio
Novelty:  0.04664225
p_int:  0.999418371
p_ni:  0.000581608
p_wrong:  2.1e-8
Score:  0.951
Data Source:  BioPlex,STRINGDB
MAPK8IP1
Tbio
Family:  Enzyme
Novelty:  0.00284875
p_int:  0.99918993
p_ni:  0.00081007
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Metabolism of proteins (R-HSA-392499)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of proteins
Reactome
Neddylation
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Metabolism of proteins
Neddylation
Post-translational protein modification
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
74
eosinophil percentage of leukocytes
1
1
1
61.4
eosinophil count
1
1
1
59
IGF-1 measurement
1
1
1
49.5
Dupuytren Contracture
1
1
0
1.3
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
74
eosinophil percentage of leukocytes
1
61.4
eosinophil count
1
59
IGF-1 measurement
1
49.5
Dupuytren Contracture
0
1.3
45.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fem-1 homolog B
VGNC:14641
467716
Macaque
fem-1 homolog B
693955
Mouse
MGI:1335087
14155
Rat
RGD:1304569
315745
Dog
fem-1 homolog B
VGNC:40816
478352
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fem-1 homolog B
Macaque
fem-1 homolog B
Mouse
Rat
Dog
fem-1 homolog B
Publication Statistics
PubMed Score 18.05
PubMed score by year
PubTator Score 8.41
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title