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Tchem
FECH
Ferrochelatase, mitochondrial

Protein Summary
Description
Catalyzes the ferrous insertion into protoporphyrin IX. The protein encoded by this gene is localized to the mitochondrion, where it catalyzes the insertion of the ferrous form of iron into protoporphyrin IX in the heme synthesis pathway. Mutations in this gene are associated with erythropoietic protoporphyria. Two transcript variants encoding different isoforms have been found for this gene. A pseudogene of this gene is found on chromosome 3.[provided by RefSeq, May 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262093
  • ENSP00000262093
  • ENSG00000066926
  • ENST00000382873
  • ENSP00000372326

Symbol
  • EPP
  • FCE
  • EPP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.99
disease perturbation
0.93
biological process
0.9
kinase perturbation
0.84
molecular function
0.81


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.26   (req: < 5)
Gene RIFs: 53   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 350.26   (req: >= 5)
Gene RIFs: 53   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (167)
ATPAF2
Tbio
Family:  Enzyme
Novelty:  0.04184643
p_int:  0.999995567
p_ni:  0.000004433
Score:  0.203
Data Source:  BioPlex,STRINGDB
NELFB
Tbio
Novelty:  0.05821821
p_int:  0.999994081
p_ni:  0.000005919
Score:  0.768
Data Source:  BioPlex,STRINGDB
NELFCD
Tbio
Novelty:  0.00094754
p_int:  0.999990523
p_ni:  0.000009476
p_wrong:  1e-9
Score:  0.691
Data Source:  BioPlex,STRINGDB
PPP2R1A
Tbio
Family:  Enzyme
Novelty:  0.01134139
p_int:  0.999977586
p_ni:  0.000022414
Score:  0.495
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.999965195
p_ni:  0.000034805
Score:  0.522
Data Source:  BioPlex,STRINGDB
MMP26
Tchem
Family:  Enzyme
Novelty:  0.02180874
p_int:  0.999931943
p_ni:  0.000068057
Score:  0.156
Data Source:  BioPlex,STRINGDB
FMC1
Tbio
Novelty:  0.06702205
p_int:  0.999927739
p_ni:  0.000072205
p_wrong:  5.6e-8
Score:  0.305
Data Source:  BioPlex,STRINGDB
TIMP2
Tbio
Family:  Enzyme
Novelty:  0.00064016
p_int:  0.999849703
p_ni:  0.000150296
p_wrong:  1e-9
Score:  0.534
Data Source:  BioPlex,STRINGDB
UBL4B
Tdark
Novelty:  0.56877836
p_int:  0.999623503
p_ni:  0.000376497
Data Source:  BioPlex
NELFE
Tbio
Novelty:  0.02136256
p_int:  0.998892117
p_ni:  0.00110788
p_wrong:  4e-9
Score:  0.691
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Heme biosynthesis (R-HSA-189451)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Heme biosynthesis
Reactome
Metabolism
Reactome
Metabolism of porphyrins
Name
Explore in Pharos
Explore in Source
Heme biosynthesis
Metabolism
Metabolism of porphyrins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
4
3
4.8
96.1
aspartate aminotransferase measurement
2
2
1
14.1
92.4
serum alanine aminotransferase measurement
1
1
1
79.9
hematocrit
2
2
2
77
hemoglobin measurement
2
2
2
75
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
4.8
96.1
aspartate aminotransferase measurement
1
14.1
92.4
serum alanine aminotransferase measurement
1
79.9
hematocrit
2
77
hemoglobin measurement
2
75
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ferrochelatase
VGNC:5169
455437
Macaque
ferrochelatase
695759
Mouse
MGI:95513
14151
Rat
RGD:1307556
361338
Dog
ferrochelatase
VGNC:40815
610360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ferrochelatase
Macaque
ferrochelatase
Mouse
Rat
Dog
ferrochelatase
Publication Statistics
PubMed Score 350.26
PubMed score by year
PubTator Score 466.74
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title