Tclin FDPS Farnesyl pyrophosphate synthase

Protein Summary

Description

Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate. This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P14324
• D3DV91
• E9PCI9
• Q96G29
• FPP synthase

Gene Name

• FDPS

Ensembl ID

• ENST00000356657
• ENSP00000349078
• ENSG00000160752
• ENST00000368356
• ENSP00000357340
• ENST00000447866
• ENSP00000391755
• ENST00000467076
• ENSP00000480142
• ENST00000612683
• ENSP00000478235

Symbol

• FPS
• KIAA1293
• FPS
• FPPS
• POROK9

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.88
kinase perturbation	0.81
ligand (chemical)	0.8
transcription factor perturbation	0.74
small molecule perturbation	0.71

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Farnesyl Pyrophosphate Synthase

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Farnesyl Pyrophosphate Synthase

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 759.71   (req: < 5)

Gene RIFs: 35   (req: <= 3)

Antibodies: 349   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 759.71   (req: >= 5)

Gene RIFs: 35   (req: > 3)

Antibodies: 349   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 212

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 6