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Tchem
FDFT1
Squalene synthase

Protein Summary
Description
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000220584
  • ENSP00000220584
  • ENSG00000079459
  • ENST00000443614
  • ENSP00000390367
  • ENST00000525777
  • ENSP00000436069
  • ENST00000528643
  • ENSP00000431649
  • ENST00000528812
  • ENSP00000431749
  • ENST00000530664
  • ENSP00000432331
  • ENST00000538689
  • ENSP00000444248
  • ENST00000615631
  • ENSP00000481481
  • ENST00000618539
  • ENSP00000480828
  • ENST00000622850
  • ENSP00000484122
  • ENST00000623368
  • ENSP00000485229

Symbol
  • SS
  • SQS
  • DGPT
  • ERG9
  • SQSD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
transcription factor perturbation
1
kinase perturbation
0.99
disease perturbation
0.97
interacting protein
0.95


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 634.06   (req: < 5)
Gene RIFs: 21   (req: <= 3)
Antibodies: 401   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 634.06   (req: >= 5)
Gene RIFs: 21   (req: > 3)
Antibodies: 401   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 208
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1