Tbio FCRLA Fc receptor-like A

Protein Summary

Description

May be implicated in B-cell differentiation and lymphomagenesis. This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Uniprot Accession IDs

• Q7L513
• A0N0M1
• A6NC03
• A6NL20
• F5H720
• F8W743
• G3V1J2
• Q5VXA1
• Q5VXA2
• Q5VXA3
• Q5VXA4
• Q5VXB0
• Q5VXB1
• Q8NEW4
• Q8WXH3
• Q96PC6
• Q96PJ0
• Q96PJ1
• Q96PJ2
• Q96PJ4
• Q9BR57

Gene Name

• FCRLA

Ensembl ID

• ENST00000236938
• ENSP00000236938
• ENSG00000132185
• ENST00000294796
• ENSP00000294796
• ENST00000309691
• ENSP00000309596
• ENST00000349527
• ENSP00000294798
• ENST00000350710
• ENSP00000344808
• ENST00000367949
• ENSP00000356926
• ENST00000367953
• ENSP00000356930
• ENST00000367957
• ENSP00000356934
• ENST00000367959
• ENSP00000356936
• ENST00000540521
• ENSP00000442870
• ENST00000546024
• ENSP00000439838

Symbol

• FCRL
• FCRL1
• FCRLM1
• FCRX
• FREB
• FCRL
• FCRX
• FREB
• FCRL1
• FCRLX
• FCRLb
• FCRLd
• FCRLe
• FCRLM1
• FCRLc1
• FCRLc2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.93
tissue sample	0.71
gene perturbation	0.68
kinase perturbation	0.48
tissue	0.47

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Fc Receptor-like A

DTO Classes

Protein / Cell Adhesion / Fc Receptor-like A

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.61   (req: < 5)

Gene RIFs: 11   (req: <= 3)

Antibodies: 105   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 56.61   (req: >= 5)

Gene RIFs: 11   (req: > 3)

Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0