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Tbio
FCRLA
Fc receptor-like A

Protein Summary
Description
May be implicated in B-cell differentiation and lymphomagenesis. This gene encodes a protein similar to receptors for the Fc fragment of gamma immunoglobulin (IgG). These receptors, referred to as FCGRs, mediate the destruction of IgG-coated antigens and of cells induced by antibodies. This encoded protein is selectively expressed in B cells, and may be involved in their development. This protein may also be involved in the development of lymphomas. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236938
  • ENSP00000236938
  • ENSG00000132185
  • ENST00000294796
  • ENSP00000294796
  • ENST00000309691
  • ENSP00000309596
  • ENST00000349527
  • ENSP00000294798
  • ENST00000350710
  • ENSP00000344808
  • ENST00000367949
  • ENSP00000356926
  • ENST00000367953
  • ENSP00000356930
  • ENST00000367957
  • ENSP00000356934
  • ENST00000367959
  • ENSP00000356936
  • ENST00000540521
  • ENSP00000442870
  • ENST00000546024
  • ENSP00000439838

Symbol
  • FCRL
  • FCRL1
  • FCRLM1
  • FCRX
  • FREB
  • FCRL
  • FCRX
  • FREB
  • FCRL1
  • FCRLX
  • FCRLb
  • FCRLd
  • FCRLe
  • FCRLM1
  • FCRLc1
  • FCRLc2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.93
tissue sample
0.71
gene perturbation
0.68
kinase perturbation
0.48
tissue
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.48   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 105   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 46.48   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 105   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (28)
CD19
Tclin
Novelty:  0.0001816
Score:  0.852
Data Source:  STRINGDB
VPREB3
Tbio
Novelty:  0.13999956
Score:  0.824
Data Source:  STRINGDB
CD79B
Tclin
Novelty:  0.00227414
Score:  0.77
Data Source:  STRINGDB
CD79A
Tbio
Novelty:  0.00118942
Score:  0.768
Data Source:  STRINGDB
MEIS1
Tbio
Family:  TF
Novelty:  0.00480433
Score:  0.759
Data Source:  STRINGDB
NUP98
Tbio
Family:  Enzyme
Novelty:  0.00401452
Score:  0.718
Data Source:  STRINGDB
HOXA9
Tbio
Family:  TF
Novelty:  0.00249963
Score:  0.718
Data Source:  STRINGDB
BLK
Tchem
Family:  Kinase
Novelty:  0.00480349
Score:  0.712
Data Source:  STRINGDB
MS4A1
Tclin
Novelty:  0.00701134
Score:  0.677
Data Source:  STRINGDB
TNFRSF13C
Tbio
Novelty:  0.00198038
Score:  0.607
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (2)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Disease Associations (null)
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
2
18
18
99.9
blood protein measurement
2
16
16
99.8
aspartate aminotransferase measurement
2
2
1
10.9
93.9
basophil percentage of leukocytes
1
2
2
91.1
leukocyte count
3
4
4
89.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
18
99.9
blood protein measurement
16
99.8
aspartate aminotransferase measurement
1
10.9
93.9
basophil percentage of leukocytes
2
91.1
leukocyte count
4
89.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fc receptor like A
VGNC:6824
457460
Macaque
Fc receptor like A
720016
Mouse
MGI:2138647
98752
Rat
RGD:1306176
304965
Dog
Fc receptor like A
VGNC:40810
488658
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fc receptor like A
Macaque
Fc receptor like A
Mouse
Rat
Dog
Fc receptor like A
Publication Statistics
PubMed Score 46.48
PubMed score by year
PubTator Score 39.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title