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Tbio
FCRL4
Fc receptor-like protein 4

Protein Summary
Description
May function as an inhibitor of the B-cell receptor signaling. May function in the B-cell-mediated immune response. This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein has four extracellular C2-type immunoglobulin domains, a transmembrane domain and a cytoplasmic domain that contains three immune-receptor tyrosine-based inhibitory motifs. This protein may play a role in the function of memory B-cells in the epithelia. Aberrations in the chromosomal region encoding this gene are associated with non-Hodgkin lymphoma and multiple myeloma. [provided by RefSeq, Apr 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000271532
  • ENSP00000271532
  • ENSG00000163518

Symbol
  • FCRH4
  • IFGP2
  • IRTA1
  • FCRH4
  • IGFP2
  • IRTA1
  • CD307d
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.58
cellular component
0.53
microRNA
0.5
cell line
0.44
cell type or tissue
0.41


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.22   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 190   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.22   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 190   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (23)
ADO
Tbio
Family:  Enzyme
Novelty:  0.04529593
p_int:  0.999977026
p_ni:  0.000022967
p_wrong:  7e-9
Score:  0.416
Data Source:  BioPlex,STRINGDB
MUC15
Tbio
Novelty:  0.02213624
p_int:  0.997232447
p_ni:  0.002765484
p_wrong:  0.000002069
Score:  0.556
Data Source:  BioPlex,STRINGDB
MOCS1
Tclin
Novelty:  0.02785369
p_int:  0.979748272
p_ni:  0.02024379
p_wrong:  0.000007938
Score:  0.325
Data Source:  BioPlex,STRINGDB
PIGR
Tbio
Novelty:  0.0025812
Score:  0.751
Data Source:  STRINGDB
BCL9
Tbio
Novelty:  0.01853613
Score:  0.711
Data Source:  STRINGDB
CR2
Tbio
Novelty:  0.00086638
Score:  0.648
Data Source:  STRINGDB
CD27
Tbio
Novelty:  0.00090508
Score:  0.644
Data Source:  STRINGDB
C1GALT1
Tbio
Family:  Enzyme
Novelty:  0.01191596
Score:  0.624
Data Source:  STRINGDB
C1GALT1C1
Tbio
Family:  Enzyme
Novelty:  0.01318017
Score:  0.621
Data Source:  STRINGDB
CD19
Tclin
Novelty:  0.0001816
Score:  0.555
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
1
1
57.8
granulocyte count
1
1
1
32.7
1
1
0
1.1
3.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
myeloid white cell count
1
57.8
granulocyte count
1
32.7
0
1.1
3.2
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fc receptor like 4
VGNC:7406
744536
Macaque
Fc receptor like 4
718784
Dog
Fc receptor like 4
VGNC:40809
490400
Horse
Fc receptor like 4
VGNC:17981
102150909
Pig
Fc receptor like 4
100156890
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fc receptor like 4
Macaque
Fc receptor like 4
Dog
Fc receptor like 4
Horse
Fc receptor like 4
Pig
Fc receptor like 4
Publication Statistics
PubMed Score 35.22
PubMed score by year
PubTator Score 29.21
PubTator score by year
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Related Publications
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PMID
Year
Title