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Tbio
FCN3
Ficolin-3

Protein Summary
Description
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota. Ficolins are a group of proteins which consist of a collagen-like domain and a fibrinogen-like domain. In human serum, there are two types of ficolins, both of which have lectin activity. The protein encoded by this gene is a thermolabile beta-2-macroglycoprotein found in all human serum and is a member of the ficolin/opsonin p35 lectin family. The protein, which was initially identified based on its reactivity with sera from patients with systemic lupus erythematosus, has been shown to have a calcium-independent lectin activity. The protein can activate the complement pathway in association with MASPs and sMAP, thereby aiding in host defense through the activation of the lectin pathway. Alternative splicing occurs at this locus and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270879
  • ENSP00000270879
  • ENSG00000142748
  • ENST00000354982
  • ENSP00000347077

Symbol
  • FCNH
  • HAKA1
  • FCNH
  • HAKA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
tissue sample
0.65
biological process
0.58
biological term
0.53
tissue
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.69   (req: < 5)
Gene RIFs: 47   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 137.69   (req: >= 5)
Gene RIFs: 47   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (25)
MBL2
Tbio
Novelty:  0.00124156
Score:  0.988
Data Source:  STRINGDB
MASP1
Tchem
Family:  Enzyme
Novelty:  0.0029019
Score:  0.981
Data Source:  Reactome,STRINGDB
COLEC11
Tbio
Novelty:  0.02989413
Score:  0.973
Data Source:  STRINGDB
COLEC10
Tbio
Novelty:  0.02593638
Score:  0.962
Data Source:  STRINGDB
C4A
Tbio
Novelty:  0.00062793
Score:  0.958
Data Source:  STRINGDB
C4B
Tbio
Novelty:  0.00068357
Score:  0.958
Data Source:  STRINGDB
C2
Tchem
Novelty:  0.00974862
Score:  0.934
Data Source:  STRINGDB
FCN2
Tbio
Novelty:  0.00519137
Score:  0.911
Data Source:  STRINGDB
MASP2
Tchem
Family:  Enzyme
Novelty:  0.00466852
Score:  0.908
Data Source:  Reactome,STRINGDB
FCN1
Tbio
Novelty:  0.01037775
Score:  0.906
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Reactome
Immune System
Reactome
Initial triggering of complement
Name
Explore in Pharos
Explore in Source
Complement cascade
Creation of C4 and C2 activators
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Immune System
Initial triggering of complement
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ficolin 3
VGNC:6819
738452
Macaque
ficolin 3
720154
Horse
ficolin 3
VGNC:17980
100070924
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ficolin 3
Macaque
ficolin 3
Horse
ficolin 3
Publication Statistics
PubMed Score 137.69
PubMed score by year
PubTator Score 78.40
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title