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Tbio
FCN2
Ficolin-2

Protein Summary
Description
May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc-binding lectin. Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect via the collagen region. The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000291744
  • ENSP00000291744
  • ENSG00000160339
  • ENST00000350339
  • ENSP00000291741

Symbol
  • FCNL
  • P35
  • FCNL
  • EBP-37
  • ficolin-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.74
protein domain
0.73
biological term
0.68
tissue
0.56
phenotype
0.52


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.93   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 203   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 230.93   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 203   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (36)
FCN1
Tbio
Novelty:  0.01037775
p_int:  0.999999754
p_wrong:  2.46e-7
Score:  0.938
Data Source:  BioPlex,STRINGDB
MASP1
Tchem
Family:  Enzyme
Novelty:  0.0029019
Score:  0.994
Data Source:  Reactome,STRINGDB
MBL2
Tbio
Novelty:  0.00124156
Score:  0.994
Data Source:  STRINGDB
C4B
Tbio
Novelty:  0.00068357
Score:  0.967
Data Source:  STRINGDB
COLEC10
Tbio
Novelty:  0.02593638
Score:  0.967
Data Source:  STRINGDB
C4A
Tbio
Novelty:  0.00062793
Score:  0.966
Data Source:  STRINGDB
MASP2
Tchem
Family:  Enzyme
Novelty:  0.00466852
Score:  0.951
Data Source:  Reactome,STRINGDB
C2
Tchem
Novelty:  0.00974862
Score:  0.946
Data Source:  STRINGDB
COLEC11
Tbio
Novelty:  0.02989413
Score:  0.939
Data Source:  STRINGDB
FCN3
Tbio
Novelty:  0.00771958
Score:  0.911
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (15)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Creation of C4 and C2 activators
Reactome
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Reactome
Immune System
Reactome
Initial triggering of complement
Name
Explore in Pharos
Explore in Source
Complement cascade
Creation of C4 and C2 activators
Ficolins bind to repetitive carbohydrate structures on the target cell surface
Immune System
Initial triggering of complement
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
1
2
26.1
myeloid white cell count
1
1
1
21.5
leukocyte count
1
1
1
10.8
neutrophil percentage of leukocytes
1
1
1
8.4
monocyte percentage of leukocytes
1
1
1
3.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
2
26.1
myeloid white cell count
1
21.5
leukocyte count
1
10.8
neutrophil percentage of leukocytes
1
8.4
monocyte percentage of leukocytes
1
3.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (2)
1 – 2 of 2
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ficolin 2
712486
Mouse
MGI:1341158
14134
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ficolin 2
Mouse
Publication Statistics
PubMed Score 230.93
PubMed score by year
PubTator Score 130.45
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title