Protein Summary
Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encod ...more
- ENST00000371806
- ENSP00000360871
- ENSG00000085265
- FCNM
- FCNM
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 0.73 | ||
protein domain | 0.73 | ||
biological process | 0.69 | ||
cellular component | 0.6 | ||
biological term | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 98.08 (req: < 5)
Gene RIFs: 38 (req: <= 3)
Antibodies: 344 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 98.08 (req: >= 5)
Gene RIFs: 38 (req: > 3)
Antibodies: 344 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 15
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (59)
FCN2
Novelty: 0.00519137
p_int: 0.999999754
p_wrong: 2.46e-7
Score: 0.938
Data Source: BioPlex,STRINGDB
SUSD5
Novelty: 1.0992718
p_int: 0.999999125
p_ni: 8.72e-7
p_wrong: 2e-9
Score: 0.209
Data Source: BioPlex,STRINGDB
SEZ6L2
Novelty: 0.02623263
p_int: 0.999956044
p_ni: 0.000043956
p_wrong: 1e-9
Score: 0.257
Data Source: BioPlex,STRINGDB
PODXL
Novelty: 0.00306913
p_int: 0.999947112
p_ni: 0.000052888
Score: 0.188
Data Source: BioPlex,STRINGDB
DNAJC13
Novelty: 0.03251995
p_int: 0.999911552
p_ni: 0.000088448
Score: 0.207
Data Source: BioPlex,STRINGDB
KIAA0319L
Novelty: 0.02873675
p_int: 0.996159912
p_ni: 0.003840083
p_wrong: 5e-9
Score: 0.184
Data Source: BioPlex,STRINGDB
PTPRA
Family: Enzyme
Novelty: 0.01392344
p_int: 0.992913137
p_ni: 0.00708686
p_wrong: 3e-9
Score: 0.224
Data Source: BioPlex,STRINGDB
PTPRG
Family: Enzyme
Novelty: 0.01920574
p_int: 0.968460005
p_ni: 0.031539947
p_wrong: 4.8e-8
Score: 0.197
Data Source: BioPlex,STRINGDB
KIAA1549
Novelty: 0.01224835
p_int: 0.911121203
p_ni: 0.000404104
p_wrong: 0.088474693
Score: 0.187
Data Source: BioPlex,STRINGDB
TRABD
Novelty: 0.47132923
p_int: 0.894042841
p_ni: 0.105760088
p_wrong: 0.000197071
Score: 0.187
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (19)
Reactome (8)
WikiPathways (11)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Complement cascade | ||||
Reactome | Creation of C4 and C2 activators | ||||
Reactome | Ficolins bind to repetitive carbohydrate structures on the target cell surface | ||||
Reactome | Immune System | ||||
Reactome | Initial triggering of complement | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Complement cascade | ||||
Creation of C4 and C2 activators | ||||
Ficolins bind to repetitive carbohydrate structures on the target cell surface | ||||
Immune System | ||||
Initial triggering of complement | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (6)
Components (6)
Processes (9)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
neutrophil count | 2 | 1 | 2 | 26.1 | |||||
myeloid white cell count | 1 | 1 | 1 | 21.5 | |||||
leukocyte count | 1 | 1 | 1 | 10.8 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 8.4 | |||||
skin barrier function measurement | 1 | 1 | 1 | 4.7 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
neutrophil count | 2 | 26.1 | |||||
myeloid white cell count | 1 | 21.5 | |||||
leukocyte count | 1 | 10.8 | |||||
neutrophil percentage of leukocytes | 1 | 8.4 | |||||
skin barrier function measurement | 1 | 4.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | ficolin 1 | VGNC:4734 | 464840 | |||||
Macaque | ficolin 1 | 712405 | ||||||
Mouse | MGI:1341158 | 14134 | ||||||
Rat | RGD:621222 | 114091 | ||||||
Dog | ficolin 2 | 608247 | ||||||
Publication Statistics
PubMed Score 98.08
PubMed score by year
PubTator Score 66.98
PubTator score by year
Related Publications
Text Mined References (56)
GeneRif Annotations (38)
Items per page:
0 of 0
PMID | Year | Title |
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