Tbio FCN1 Ficolin-1

Protein Summary

Description

Extracellular lectin functioning as a pattern-recognition receptor in innate immunity. Binds the sugar moieties of pathogen-associated molecular patterns (PAMPs) displayed on microbes and activates the lectin pathway of the complement system. May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage. The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O00602
• Q5VYV5
• Q92596

Gene Name

• FCN1

Ensembl ID

• ENST00000371806
• ENSP00000360871
• ENSG00000085265

Symbol

• FCNM
• FCNM

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.73
protein domain	0.73
biological process	0.69
cellular component	0.6
biological term	0.58

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Ficolin-1

DTO Classes

Protein / Signaling / Ficolin-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.08   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 344   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.08   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 344   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (59)

Explore Interacting Targets

1 – 10 of 59

• See Interactions on String-DB

FCN2

Tbio

Novelty:  0.00519137

p_int:  0.999999754

p_wrong:  2.46e-7

Score:  0.938

Data Source:  BioPlex,STRINGDB

SUSD5

Tdark

Novelty:  1.0992718

p_int:  0.999999125

p_ni:  8.72e-7

p_wrong:  2e-9

Score:  0.209

Data Source:  BioPlex,STRINGDB

SEZ6L2

Tbio

Novelty:  0.02623263

p_int:  0.999956044

p_ni:  0.000043956

p_wrong:  1e-9

Score:  0.257

Data Source:  BioPlex,STRINGDB

PODXL

Tbio

Novelty:  0.00306913

p_int:  0.999947112

p_ni:  0.000052888

Score:  0.188

Data Source:  BioPlex,STRINGDB

DNAJC13

Tbio

Novelty:  0.03251995

p_int:  0.999911552

p_ni:  0.000088448

Score:  0.207

Data Source:  BioPlex,STRINGDB

KIAA0319L

Tbio

Novelty:  0.02873675

p_int:  0.996159912

p_ni:  0.003840083

p_wrong:  5e-9

Score:  0.184

Data Source:  BioPlex,STRINGDB

PTPRA

Tchem

Family:  Enzyme

Novelty:  0.01392344

p_int:  0.992913137

p_ni:  0.00708686

p_wrong:  3e-9

Score:  0.224

Data Source:  BioPlex,STRINGDB

PTPRG

Tchem

Family:  Enzyme

Novelty:  0.01920574

p_int:  0.968460005

p_ni:  0.031539947

p_wrong:  4.8e-8

Score:  0.197

Data Source:  BioPlex,STRINGDB

KIAA1549

Tbio

Novelty:  0.01224835

p_int:  0.911121203

p_ni:  0.000404104

p_wrong:  0.088474693

Score:  0.187

Data Source:  BioPlex,STRINGDB

TRABD

Tdark

Novelty:  0.47132923

p_int:  0.894042841

p_ni:  0.105760088

p_wrong:  0.000197071

Score:  0.187

Data Source:  BioPlex,STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (19)

Reactome (8)

WikiPathways (11)

Complement cascade (R-HSA-166658)

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5

1 – 5 of 8

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Complement cascade	133 targets	R-HSA-166658
Reactome	Creation of C4 and C2 activators	91 targets	R-HSA-166786
Reactome	Ficolins bind to repetitive carbohydrate structures on the target cell surface	5 targets	R-HSA-2855086
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Initial triggering of complement	98 targets	R-HSA-166663

Name	Explore in Pharos	Explore in Source
Complement cascade	133 targets	R-HSA-166658
Creation of C4 and C2 activators	91 targets	R-HSA-166786
Ficolins bind to repetitive carbohydrate structures on the target cell surface	5 targets	R-HSA-2855086
Immune System	2246 targets	R-HSA-168256
Initial triggering of complement	98 targets	R-HSA-166663

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (21)

Functions (6)

Components (6)

Processes (9)

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Items per page:

10

1 – 6 of 6

GO Term	Evidence	Assigned by
sialic acid binding	Inferred from Direct Assay (IDA)	UniProtKB
G protein-coupled receptor binding	Inferred from Physical Interaction (IPI)	UniProtKB
signaling pattern recognition receptor activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
serine-type endopeptidase activity	Traceable Author Statement (TAS)	Reactome
carbohydrate binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Disease Associations ()

No disease associations found

GWAS Traits (6)

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

1 – 5 of 6

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2	1	2		26.1
myeloid white cell count	EFO_0007988	1	1	1		21.5
leukocyte count	EFO_0004308	1	1	1		10.8
neutrophil percentage of leukocytes	EFO_0007990	1	1	1		8.4
skin barrier function measurement	EFO_0007891	1	1	1		4.7

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 6

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
neutrophil count	EFO_0004833	2		26.1
myeloid white cell count	EFO_0007988	1		21.5
leukocyte count	EFO_0004308	1		10.8
neutrophil percentage of leukocytes	EFO_0007990	1		8.4
skin barrier function measurement	EFO_0007891	1		4.7

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Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Calcium
Cell membrane
Collagen
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunity
Innate immunity

GWAS Trait Find Similar Targets

No Header	No Header
leukocyte count
monocyte percentage of leukocytes
myeloid white cell count
neutrophil count
neutrophil percentage of leukocytes
skin barrier function measurement

MGI Phenotype Find Similar Targets

No Header	No Header
immune system phenotype
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	ficolin 1	VGNC:4734	464840
Macaque	ficolin 1		712405
Mouse	ficolin B	MGI:1341158	14134
Rat	ficolin B	RGD:621222	114091
Dog	ficolin 2		608247

Species	Name	OMA	EggNOG	Inparanoid
Chimp	ficolin 1
Macaque	ficolin 1
Mouse	ficolin B
Rat	ficolin B
Dog	ficolin 2

Publication Statistics

PubMed Score 98.08

PubMed score by year

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PubTator Score 66.98

PubTator score by year

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Related Publications

Text Mined References (56)

GeneRif Annotations (38)

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PMID	Year	Title