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Tbio
FCHO1
F-BAR domain only protein 1

Protein Summary
Description
Functions in an early step of clathrin-mediated endocytosis. Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000252771
  • ENSP00000252771
  • ENSG00000130475
  • ENST00000595033
  • ENSP00000472668
  • ENST00000596536
  • ENSP00000470731
  • ENST00000596951
  • ENSP00000472417
  • ENST00000600676
  • ENSP00000470493

Symbol
  • KIAA0290
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor
0.73
disease perturbation
0.68
gene perturbation
0.68
protein domain
0.58
tissue sample
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.91   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.91   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (143)
FCHO2
Tbio
Novelty:  0.12302279
p_int:  0.999999925
p_ni:  6.6e-8
p_wrong:  9e-9
Score:  0.924
Data Source:  BioPlex,STRINGDB
PCGF1
Tbio
Novelty:  0.06481661
p_int:  0.999948056
p_ni:  0.000051944
p_wrong:  1e-9
Score:  0.191
Data Source:  BioPlex,STRINGDB
EPS15
Tchem
Novelty:  0.00451447
p_int:  0.999855042
p_ni:  0.000144902
p_wrong:  5.6e-8
Score:  0.99
Data Source:  BioPlex,STRINGDB
EPS15L1
Tbio
Novelty:  0.06929299
p_int:  0.998627369
p_ni:  0.001372631
Score:  0.984
Data Source:  BioPlex,STRINGDB
AP2A1
Tbio
Novelty:  0.08554974
p_int:  0.993652387
p_ni:  0.006347613
Score:  0.956
Data Source:  BioPlex,STRINGDB
AP2A2
Tbio
Novelty:  0.08851191
p_int:  0.987943329
p_ni:  0.012056671
Score:  0.937
Data Source:  BioPlex,STRINGDB
SRR
Tbio
Family:  Enzyme
Novelty:  0.00425993
p_int:  0.916075941
p_ni:  0.083924059
Score:  0.309
Data Source:  BioPlex,STRINGDB
AP1B1
Tbio
Novelty:  0.03370208
p_int:  0.900978613
p_ni:  0.099021387
Score:  0.42
Data Source:  BioPlex,STRINGDB
TRIP10
Tbio
Novelty:  0.01553463
Score:  0.983
Data Source:  STRINGDB
FNBP1
Tbio
Novelty:  0.03879767
Score:  0.979
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

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Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
Membrane Trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
Membrane Trafficking
Vesicle-mediated transport
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (17)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
1
1
83.1
4
3
4
76.7
cancer antigen 19.9 measurement
1
1
1
57.8
basophil count
1
1
1
53.7
2
1
0
1.1
53.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
1
83.1
4
76.7
cancer antigen 19.9 measurement
1
57.8
basophil count
1
53.7
0
1.1
53.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FCH domain only 1
VGNC:2407
748541
Macaque
FCH domain only 1
720018
Mouse
MGI:1921265
74015
Dog
FCH domain only 1
VGNC:40804
476673
Cow
FCH domain only 1
VGNC:28935
505672
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FCH domain only 1
Macaque
FCH domain only 1
Mouse
Dog
FCH domain only 1
Cow
FCH domain only 1
Publication Statistics
PubMed Score 15.91
PubMed score by year
PubTator Score 4.70
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title