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Tbio
FCGR3B
Low affinity immunoglobulin gamma Fc region receptor III-B

Protein Summary
Description
Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils. The protein encoded by this gene is a low affinity receptor for the Fc region of gamma immunoglobulins (IgG). The encoded protein acts as a monomer and can bind either monomeric or aggregated IgG. This gene may function to capture immune complexes in the peripheral circulation. Several transcript variants encoding different isoforms have been found for this gene. A highly-similar gene encoding a related protein is also found on chromosome 1. [provided by RefSeq, Aug 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000294800
  • ENSP00000294800
  • ENSG00000162747
  • ENST00000367964
  • ENSP00000356941

Symbol
  • CD16B
  • FCG3
  • FCGR3
  • IGFR3
  • CD16
  • FCG3
  • CD16A
  • CD16b
  • FCGR3
  • FCGR3A
  • FCR-10
  • FCRIII
  • FCRIIIb
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
0.81
biological term
0.79
microRNA
0.79
PubMedID
0.74
disease
0.67


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2124.29   (req: < 5)
Gene RIFs: 119   (req: <= 3)
Antibodies: 539   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2124.29   (req: >= 5)
Gene RIFs: 119   (req: > 3)
Antibodies: 539   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (159)
KLHL20
Tbio
Novelty:  0.12205871
p_int:  0.999810382
p_ni:  2.7e-8
p_wrong:  0.000189591
Data Source:  BioPlex
LRRC8C
Tbio
Novelty:  0.11920205
p_int:  0.999518124
p_ni:  0.00048186
p_wrong:  1.6e-8
Score:  0.19
Data Source:  BioPlex,STRINGDB
ICK
Tchem
Family:  Kinase
Novelty:  0.00810476
p_int:  0.987816485
p_ni:  0.010481735
p_wrong:  0.00170178
Score:  0.186
Data Source:  BioPlex,STRINGDB
LRRC8E
Tbio
Novelty:  0.15689344
p_int:  0.984797784
p_ni:  0.015202213
p_wrong:  3e-9
Score:  0.211
Data Source:  BioPlex,STRINGDB
NPTX1
Tbio
Novelty:  0.02872516
p_int:  0.957837054
p_ni:  0.042162946
Data Source:  BioPlex
TUBB3
Tclin
Novelty:  0.00195963
p_int:  0.95689816
p_ni:  0.04310184
Data Source:  BioPlex
TUBB8
Tclin
Novelty:  0.06403117
p_int:  0.949487421
p_ni:  0.050512569
p_wrong:  1e-8
Data Source:  BioPlex
NRP2
Tbio
Novelty:  0.00764179
p_int:  0.930628064
p_ni:  0.068502622
p_wrong:  0.000869314
Score:  0.183
Data Source:  BioPlex,STRINGDB
COX16
Tbio
Family:  Enzyme
Novelty:  0.20901823
p_int:  0.910410159
p_ni:  0.089505875
p_wrong:  0.000083966
Score:  0.206
Data Source:  BioPlex,STRINGDB
ATP12A
Tchem
Family:  Transporter
Novelty:  0.00008793
p_int:  0.893487174
p_ni:  0.106512826
Data Source:  BioPlex
Pathways (15)
Immune System (R-HSA-168256)

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Find Similar Targets
Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Metabolism of proteins
Reactome
Neutrophil degranulation
Reactome
Post-translational modification: synthesis of GPI-anchored proteins
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Metabolism of proteins
Neutrophil degranulation
Post-translational modification: synthesis of GPI-anchored proteins
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (8)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (26)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
2
16
16
99.8
blood protein measurement
2
14
14
99.8
aspartate aminotransferase measurement
2
2
1
10.9
93.9
serum gamma-glutamyl transferase measurement
2
3
3
92.6
basophil percentage of leukocytes
1
3
3
91.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum non-albumin protein measurement
16
99.8
blood protein measurement
14
99.8
aspartate aminotransferase measurement
1
10.9
93.9
serum gamma-glutamyl transferase measurement
3
92.6
basophil percentage of leukocytes
3
91.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Cow
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
281766
Species
Name
OMA
EggNOG
Inparanoid
Cow
Fc fragment of IgG, low affinity IIIa, receptor (CD16a)
Publication Statistics
PubMed Score 2124.29
PubMed score by year
PubTator Score 175.51
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title