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Tclin
FCGR3A
Low affinity immunoglobulin gamma Fc region receptor III-A

Protein Summary
Description
Receptor for the Fc region of IgG. Binds complexed or aggregated IgG and also monomeric IgG. Mediates antibody-dependent cellular cytotoxicity (ADCC) and other antibody-dependent responses, such as phagocytosis. This gene encodes a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. This gene (FCGR3A) is highly similar to another nearby gene (FCGR3B) located on chromosome 1. The receptor encoded by this gene is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia. Alternatively ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000367967
  • ENSP00000356944
  • ENSG00000203747
  • ENST00000436743
  • ENSP00000416607
  • ENST00000443193
  • ENSP00000392047

Symbol
  • CD16A
  • FCG3
  • FCGR3
  • IGFR3
  • CD16
  • FCG3
  • CD16A
  • FCGR3
  • IGFR3
  • IMD20
  • FCR-10
  • FCRIII
  • FCGRIII
  • FCRIIIA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
drug
0.81
disease
0.76
tissue sample
0.67
cellular component
0.57


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2481.73   (req: < 5)
Gene RIFs: 287   (req: <= 3)
Antibodies: 2092   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2481.73   (req: >= 5)
Gene RIFs: 287   (req: > 3)
Antibodies: 2092   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4