Tbio FCGR2B Low affinity immunoglobulin gamma Fc region receptor II-b

Protein Summary

Description

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P31994
• A6H8N3
• O95649
• Q53X85
• Q5VXA9
• Q8NIA1
• IgG Fc receptor II-b

Gene Name

• FCGR2B

Ensembl ID

• ENST00000236937
• ENSP00000236937
• ENSG00000072694
• ENST00000358671
• ENSP00000351497
• ENST00000367961
• ENSP00000356938

Symbol

• CD32
• FCG2
• IGFR2
• CD32
• FCG2
• CD32B
• FCGR2
• IGFR2
• FCGR2C
• FcRII-c

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.93
transcription factor perturbation	0.91
drug	0.83
phenotype	0.8
disease	0.78

Protein Classes

PANTHER Classes

Protein / Cell Adhesion Molecule / Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-b

DTO Classes

Protein / Cell Adhesion / Low Affinity Immunoglobulin Gamma Fc Region Receptor Ii-b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 988.62   (req: < 5)

Gene RIFs: 165   (req: <= 3)

Antibodies: 745   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 988.62   (req: >= 5)

Gene RIFs: 165   (req: > 3)

Antibodies: 745   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0