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Tbio
FCGR2B
Low affinity immunoglobulin gamma Fc region receptor II-b

Protein Summary
Description
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000236937
  • ENSP00000236937
  • ENSG00000072694
  • ENST00000358671
  • ENSP00000351497
  • ENST00000367961
  • ENSP00000356938

Symbol
  • CD32
  • FCG2
  • IGFR2
  • CD32
  • FCG2
  • CD32B
  • FCGR2
  • IGFR2
  • FCGR2C
  • FcRII-c
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.93
transcription factor perturbation
0.91
drug
0.83
phenotype
0.8
disease
0.78


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 988.62   (req: < 5)
Gene RIFs: 140   (req: <= 3)
Antibodies: 745   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 988.62   (req: >= 5)
Gene RIFs: 140   (req: > 3)
Antibodies: 745   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 50
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0