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Tdark
FCF1
rRNA-processing protein FCF1 homolog

Protein Summary
Description
Essential protein involved in pre-rRNA processing and 40S ribosomal subunit assembly.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341162
  • ENSP00000344393
  • ENSG00000119616

Symbol
  • C14orf111
  • Bka
  • UTP24
  • CGI-35
  • C14orf111
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.86
virus perturbation
0.79
gene perturbation
0.76
disease perturbation
0.74
transcription factor binding site profile
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.81   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 12   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.81   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 12   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (316)
PPL
Tbio
Novelty:  0.00684645
p_int:  0.999982659
p_ni:  0.000017341
Data Source:  BioPlex
TREX2
Tbio
Family:  Enzyme
Novelty:  0.27214255
p_int:  0.999973192
p_ni:  0.000019361
p_wrong:  0.000007447
Score:  0.252
Data Source:  BioPlex,STRINGDB
SULT2B1
Tbio
Family:  Enzyme
Novelty:  0.02652128
p_int:  0.999936692
p_ni:  0.000063258
p_wrong:  5e-8
Data Source:  BioPlex
ENDOU
Tbio
Family:  Enzyme
Novelty:  0.01074988
p_int:  0.999931677
p_ni:  0.000068304
p_wrong:  1.9e-8
Data Source:  BioPlex
EVPL
Tbio
Novelty:  0.00274279
p_int:  0.999918964
p_ni:  0.000080997
p_wrong:  3.9e-8
Data Source:  BioPlex
IVL
Tbio
Novelty:  0.00147892
p_int:  0.999832315
p_ni:  0.000167685
Data Source:  BioPlex
SERPINB5
Tbio
Novelty:  0.00192585
p_int:  0.999777778
p_ni:  0.000222219
p_wrong:  3e-9
Data Source:  BioPlex
TRIM29
Tbio
Novelty:  0.02572789
p_int:  0.999701727
p_ni:  0.000298273
Data Source:  BioPlex
SERPINA12
Tbio
Novelty:  0.00549132
p_int:  0.99965556
p_ni:  0.00034444
Data Source:  BioPlex
ME1
Tchem
Novelty:  0.00553719
p_int:  0.999616576
p_ni:  0.000383424
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (6)
Major pathway of rRNA processing in the nucleolus and cytosol (R-HSA-6791226)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Major pathway of rRNA processing in the nucleolus and cytosol
Reactome
Metabolism of RNA
Reactome
rRNA modification in the nucleus and cytosol
Reactome
rRNA processing
Reactome
rRNA processing in the nucleus and cytosol
Name
Explore in Pharos
Explore in Source
Major pathway of rRNA processing in the nucleolus and cytosol
Metabolism of RNA
rRNA modification in the nucleus and cytosol
rRNA processing
rRNA processing in the nucleus and cytosol
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
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Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
5
5
3
1
93
neuroticism measurement
4
9
6
7.6
88.4
wellbeing measurement
3
3
4
85
depressive symptom measurement
1
2
2
80
worry measurement
2
4
4
6.4
75.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1
93
neuroticism measurement
6
7.6
88.4
wellbeing measurement
4
85
depressive symptom measurement
2
80
worry measurement
4
6.4
75.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FCF1, rRNA-processing protein
VGNC:7520
467509
Macaque
FCF1, rRNA-processing protein
700044
Mouse
MGI:1920986
73736
Rat
RGD:1310899
299198
Dog
FCF1, rRNA-processing protein
480386
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FCF1, rRNA-processing protein
Macaque
FCF1, rRNA-processing protein
Mouse
Rat
Dog
FCF1, rRNA-processing protein
Publication Statistics
PubMed Score 23.81
PubMed score by year
PubTator Score 19.12
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title