FCER2
Low affinity immunoglobulin epsilon Fc receptor
Protein Summary
Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen). The protein encoded by this gene is a B-cell specific antigen, and a low-affinity receptor for IgE. It has essential roles in B cell growth and differentiation, and the regulation of IgE production. This protein also exists as a soluble secreted form, then functioning as a potent mitogenic growth factor. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Jul 2011]
- ENST00000346664
- ENSP00000264072
- ENSG00000104921
- ENST00000597921
- ENSP00000471974
- CD23A
- CLEC4J
- FCE2
- IGEBF
- CD23
- FCE2
- CD23A
- IGEBF
- CLEC4J
- BLAST-2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 0.83 | ||
cell type or tissue | 0.65 | ||
protein domain | 0.58 | ||
gene perturbation | 0.56 | ||
tissue sample | 0.56 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 461.47 (req: < 5)
Gene RIFs: 90 (req: <= 3)
Antibodies: 1493 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 461.47 (req: >= 5)
Gene RIFs: 90 (req: > 3)
Antibodies: 1493 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 45
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (45)
Protein-Protein Interactions (60)
Nearest Tclin Targets
Pathways (20)
Reactome (9)
KEGG (2)
PathwayCommons (1)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Immune System | ||||
Reactome | Interleukin-10 signaling | ||||
Reactome | Interleukin-4 and Interleukin-13 signaling | ||||
Reactome | NOTCH2 intracellular domain regulates transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Immune System | ||||
Interleukin-10 signaling | ||||
Interleukin-4 and Interleukin-13 signaling | ||||
NOTCH2 intracellular domain regulates transcription | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (4)
Components (4)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (15)
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 4 | 5 | 95.6 | |||||
leukocyte count | 2 | 4 | 4 | 91.2 | |||||
resistin measurement | 1 | 2 | 0 | 6.2 | 91.1 | ||||
myeloid white cell count | 2 | 2 | 2 | 86.2 | |||||
aspartate aminotransferase measurement | 1 | 1 | 0 | 9.5 | 73.9 | ||||
Items per page:
1 – 5 of 15
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
neutrophil count | 5 | 95.6 | |||||
leukocyte count | 4 | 91.2 | |||||
resistin measurement | 0 | 6.2 | 91.1 | ||||
myeloid white cell count | 2 | 86.2 | |||||
aspartate aminotransferase measurement | 0 | 9.5 | 73.9 | ||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | Fc fragment of IgE receptor II | 456434 | ||||||
Mouse | MGI:95497 | 14128 | ||||||
Rat | RGD:619997 | 171075 | ||||||
Dog | Fc fragment of IgE receptor II | VGNC:49895 | 484998 | |||||
Horse | Fc fragment of IgE receptor II | VGNC:17974 | 100009715 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | Fc fragment of IgE receptor II | |||||
Mouse | ||||||
Rat | ||||||
Dog | Fc fragment of IgE receptor II | |||||
Horse | Fc fragment of IgE receptor II | |||||
Publication Statistics
PubMed Score 461.47
PubMed score by year
PubTator Score 969.94
PubTator score by year
Related Publications
Text Mined References (121)
GeneRif Annotations (90)
Items per page:
0 of 0
PMID | Year | Title |
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