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Tdark
FBXW12
F-box/WD repeat-containing protein 12

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000296438
  • ENSP00000296438
  • ENSG00000164049
  • ENST00000415155
  • ENSP00000414683
  • ENST00000445170
  • ENSP00000406139

Symbol
  • FBW12
  • FBXO12
  • FBXO35
  • FBW12
  • FBXO12
  • FBXO35
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.56
cell type or tissue
0.55
small molecule perturbation
0.51
cell line
0.46
chemical
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 155   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.92   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 155   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (315)
FBXL13
Tdark
Novelty:  0.33362589
Score:  0.973
Data Source:  STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.97
Data Source:  STRINGDB
FBXL4
Tbio
Novelty:  0.04286856
Score:  0.963
Data Source:  STRINGDB
FBXL19
Tbio
Novelty:  0.07526966
Score:  0.958
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.952
Data Source:  STRINGDB
FBXW9
Tdark
Novelty:  1.16615529
Score:  0.951
Data Source:  STRINGDB
FBXO41
Tbio
Novelty:  0.19719067
Score:  0.95
Data Source:  STRINGDB
FBXW11
Tbio
Novelty:  0.0715377
Score:  0.949
Data Source:  STRINGDB
FBXW10
Tbio
Novelty:  0.11629778
Score:  0.94
Data Source:  STRINGDB
FBXW2
Tbio
Novelty:  0.01492058
Score:  0.937
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
1
2
2
89.2
self reported educational attainment
2
3
3
84.1
BMI-adjusted waist circumference
1
2
2
81
mathematical ability
3
1
3
69.8
serum albumin measurement
1
1
1
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
macrophage inflammatory protein 1b measurement
2
89.2
self reported educational attainment
3
84.1
BMI-adjusted waist circumference
2
81
mathematical ability
3
69.8
serum albumin measurement
1
68.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box and WD repeat domain containing 12
VGNC:1818
100611572
Macaque
F-box and WD repeat domain containing 12
100429515
Mouse
MGI:3643290
382156
Mouse
MGI:3505701
382105
Rat
RGD:1307859
301015
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box and WD repeat domain containing 12
Macaque
F-box and WD repeat domain containing 12
Mouse
Mouse
Rat
Publication Statistics
PubMed Score 3.92
PubMed score by year
PubTator Score 2.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title