FBXW12
F-box/WD repeat-containing protein 12
Protein Summary
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
- ENST00000296438
- ENSP00000296438
- ENSG00000164049
- ENST00000415155
- ENSP00000414683
- ENST00000445170
- ENSP00000406139
- FBW12
- FBXO12
- FBXO35
- FBW12
- FBXO12
- FBXO35
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
tissue sample | 0.56 | ||
cell type or tissue | 0.55 | ||
small molecule perturbation | 0.51 | ||
cell line | 0.46 | ||
chemical | 0.41 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.92 (req: < 5)
Gene RIFs: 3 (req: <= 3)
Antibodies: 155 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 3.92 (req: >= 5)
Gene RIFs: 3 (req: > 3)
Antibodies: 155 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 3
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (315)
Nearest Tclin Targets
Pathways (7)
Reactome (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Immune System | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Immune System | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (4)
Functions (1)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Disease Associations ()
GWAS Traits (16)
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
macrophage inflammatory protein 1b measurement | 1 | 2 | 2 | 89.2 | |||||
self reported educational attainment | 2 | 3 | 3 | 84.1 | |||||
BMI-adjusted waist circumference | 1 | 2 | 2 | 81 | |||||
mathematical ability | 3 | 1 | 3 | 69.8 | |||||
serum albumin measurement | 1 | 1 | 1 | 68.6 | |||||
Items per page:
1 – 5 of 16
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
macrophage inflammatory protein 1b measurement | 2 | 89.2 | |||||
self reported educational attainment | 3 | 84.1 | |||||
BMI-adjusted waist circumference | 2 | 81 | |||||
mathematical ability | 3 | 69.8 | |||||
serum albumin measurement | 1 | 68.6 | |||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | F-box and WD repeat domain containing 12 | VGNC:1818 | 100611572 | |||||
Macaque | F-box and WD repeat domain containing 12 | 100429515 | ||||||
Mouse | MGI:3643290 | 382156 | ||||||
Mouse | MGI:3505701 | 382105 | ||||||
Rat | RGD:1307859 | 301015 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | F-box and WD repeat domain containing 12 | |||||
Macaque | F-box and WD repeat domain containing 12 | |||||
Mouse | ||||||
Mouse | ||||||
Rat | ||||||
Publication Statistics
PubMed Score 3.92
PubMed score by year
PubTator Score 2.53
PubTator score by year
Related Publications
Text Mined References (7)
GeneRif Annotations (3)
Items per page:
0 of 0
PMID | Year | Title |
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