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Tbio
FBXW10
F-box/WD repeat-containing protein 10

Protein Summary
Description
Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1. Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000301938
  • ENSP00000306937
  • ENSG00000171931
  • ENST00000308799
  • ENSP00000310382
  • ENST00000395665
  • ENSP00000379025

Symbol
  • HREP
  • Fbw10
  • SM25H2
  • SM2SH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.61
cell line
0.58
tissue sample
0.53
gene perturbation
0.5


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.4   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 74   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.4   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 74   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (317)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.973
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.969
Data Source:  STRINGDB
FBXO41
Tbio
Novelty:  0.19719067
Score:  0.962
Data Source:  STRINGDB
FBXL4
Tbio
Novelty:  0.04286856
Score:  0.962
Data Source:  STRINGDB
FBXW9
Tdark
Novelty:  1.16615529
Score:  0.956
Data Source:  STRINGDB
HECW2
Tbio
Family:  Enzyme
Novelty:  0.07194044
Score:  0.955
Data Source:  STRINGDB
FBXW4
Tbio
Novelty:  0.06255177
Score:  0.952
Data Source:  STRINGDB
FBXW5
Tbio
Novelty:  0.13100873
Score:  0.95
Data Source:  STRINGDB
FBXL22
Tdark
Novelty:  0.59436124
Score:  0.95
Data Source:  STRINGDB
FBXL15
Tbio
Novelty:  0.18567032
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
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Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Class I MHC mediated antigen processing & presentation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
1
1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
57.3
IDG Resources
No IDG generated resources found
Publication Statistics
PubMed Score 8.40
PubMed score by year
PubTator Score 2.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title