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Tbio
FBXO8
F-box only protein 8

Protein Summary
Description
May promote guanine-nucleotide exchange on an ARF. Promotes the activation of ARF through replacement of GDP with GTP (Potential). This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It contains a C-terminal amino acid sequence that bears a significant similarity with a portion of yeast Sec7p, a critical regulator of vesicular protein transport. This human protein may interact with ADP-ribosylation factor(s)(ARFs) and exhibit ARF-GEF (guanine nucleotide ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000393674
  • ENSP00000377280
  • ENSG00000164117
  • ENST00000503293
  • ENSP00000422905
  • ENST00000615392
  • ENSP00000484517

Symbol
  • FBS
  • FBX8
  • FBS
  • DC10
  • FBX8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.85
histone modification site profile
0.8
transcription factor binding site profile
0.79
tissue sample
0.61
transcription factor
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.23   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 189   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 120.23   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 189   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (63)
BIN3
Tbio
Novelty:  0.02034119
p_int:  0.999980272
p_wrong:  0.000019728
Score:  0.409
Data Source:  BioPlex,STRINGDB
ARF6
Tbio
Family:  Enzyme
Novelty:  0.00278138
Score:  0.979
Data Source:  STRINGDB
HLA-G
Tbio
Novelty:  0.0009462
Score:  0.732
Data Source:  STRINGDB
FBXO36
Tdark
Novelty:  1.95826259
Score:  0.715
Data Source:  STRINGDB
KRT18
Tbio
Novelty:  0.00069055
Score:  0.669
Data Source:  STRINGDB
FBXO34
Tdark
Novelty:  5.6683456
Score:  0.662
Data Source:  STRINGDB
LRCH1
Tbio
Novelty:  0.0923291
Score:  0.653
Data Source:  STRINGDB
FBXO16
Tdark
Novelty:  0.60353147
Score:  0.651
Data Source:  STRINGDB
PIGW
Tbio
Novelty:  0.0245774
Score:  0.648
Data Source:  STRINGDB
ARL10
Tdark
Family:  Enzyme
Novelty:  1.16329406
Score:  0.642
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chin morphology measurement
1
1
0
1.1
75.9
age at onset
1
1
0
6.6
56.3
Alzheimer disease
1
1
0
6.6
56.3
heel bone mineral density
1
1
1
33.5
bilirubin measurement
1
1
1
16.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chin morphology measurement
0
1.1
75.9
age at onset
0
6.6
56.3
Alzheimer disease
0
6.6
56.3
heel bone mineral density
1
33.5
bilirubin measurement
1
16.8
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 8
VGNC:10861
461611
Macaque
F-box protein 8
699302
Mouse
MGI:1354696
50753
Rat
RGD:1307596
306436
Dog
F-box protein 8
VGNC:40790
477359
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 8
Macaque
F-box protein 8
Mouse
Rat
Dog
F-box protein 8
Publication Statistics
PubMed Score 120.23
PubMed score by year
PubTator Score 24.68
PubTator score by year
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Related Publications
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PMID
Year
Title