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Tdark
FBXO46
F-box only protein 46

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Members of the F-box protein family, such as FBXO46, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000317683
  • ENSP00000410007
  • ENSG00000177051

Symbol
  • FBX46
  • FBXO34L
  • Fbx46
  • FBXO34L
  • 20D7-FC4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.9
transcription factor binding site profile
0.81
disease perturbation
0.68
histone modification site profile
0.65
cellular component
0.64


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.25   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 73   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.25   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (22)
DIDO1
Tbio
Family:  Epigenetic
Novelty:  0.0492858
p_int:  0.999923985
p_ni:  0.000076015
Data Source:  BioPlex
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999698104
p_ni:  0.000301896
Score:  0.653
Data Source:  BioPlex,STRINGDB
RNH1
Tbio
Family:  Enzyme
Novelty:  0.00307468
p_int:  0.999222447
p_ni:  0.000777553
Data Source:  BioPlex
EMILIN1
Tbio
Novelty:  0.02550566
p_int:  0.929444604
p_ni:  0.070555389
p_wrong:  7e-9
Score:  0.181
Data Source:  BioPlex,STRINGDB
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.915177413
p_ni:  0.084822587
Score:  0.184
Data Source:  BioPlex,STRINGDB
FSD1
Tbio
Novelty:  0.03452477
p_int:  0.877727305
p_ni:  0.122272695
Score:  0.183
Data Source:  BioPlex,STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.865304869
p_ni:  0.134695032
p_wrong:  9.9e-8
Data Source:  BioPlex
NEXN
Tbio
Novelty:  0.00745011
p_int:  0.765927327
p_ni:  0.23407219
p_wrong:  4.82e-7
Score:  0.187
Data Source:  BioPlex,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.694
Data Source:  STRINGDB
BHMG1
Tdark
Family:  TF
Novelty:  0.65960604
Score:  0.67
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations (null)
No disease associations found
GWAS Traits (53)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
17
6
23
4.2
98.2
low density lipoprotein cholesterol measurement
2
5
6
97.2
9
8
4
1.1
97.2
total cholesterol measurement
1
4
4
95
apolipoprotein B measurement
2
3
4
94.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
23
4.2
98.2
low density lipoprotein cholesterol measurement
6
97.2
4
1.1
97.2
total cholesterol measurement
4
95
apolipoprotein B measurement
4
94.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
F-box protein 46
715225
Mouse
MGI:2444918
243867
Rat
RGD:1308393
292686
Dog
F-box protein 46
VGNC:40785
612248
Horse
F-box protein 46
VGNC:51027
100065741
Species
Name
OMA
EggNOG
Inparanoid
Macaque
F-box protein 46
Mouse
Rat
Dog
F-box protein 46
Horse
F-box protein 46
Publication Statistics
PubMed Score 1.25
PubMed score by year
PubTator Score 0.20
PubTator score by year
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Related Publications
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PMID
Year
Title