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Tbio
FBXO45
F-box/SPRY domain-containing protein 1

Protein Summary
Description
Component of E3 ubiquitin ligase complexes. Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311630
  • ENSP00000310332
  • ENSG00000174013

Symbol
  • FBX45
  • Fbx45
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
microRNA
0.77
kinase perturbation
0.71
cell type or tissue
0.68
transcription factor perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.01   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 58   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 25.01   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 58   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (84)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999991488
p_ni:  0.000008507
p_wrong:  5e-9
Score:  0.923
Data Source:  BioPlex,STRINGDB
FBXW7
Tbio
Novelty:  0.00180856
p_int:  0.999968149
p_ni:  0.000007872
p_wrong:  0.000023979
Score:  0.506
Data Source:  BioPlex,STRINGDB
MMP13
Tchem
Family:  Enzyme
Novelty:  0.00057893
p_int:  0.999706516
p_ni:  0.000283778
p_wrong:  0.000009706
Data Source:  BioPlex
EPHB2
Tchem
Family:  Kinase
Novelty:  0.00211785
p_int:  0.999685567
p_ni:  0.000305167
p_wrong:  0.000009266
Data Source:  BioPlex
CDH19
Tbio
Novelty:  0.0759041
p_int:  0.999599644
p_ni:  0.000354474
p_wrong:  0.000045882
Score:  0.171
Data Source:  BioPlex,STRINGDB
LGALS3BP
Tbio
Novelty:  0.0025302
p_int:  0.999324257
p_ni:  0.000483686
p_wrong:  0.000192058
Data Source:  BioPlex
TLR10
Tbio
Novelty:  0.00817239
p_int:  0.999127098
p_ni:  0.000591436
p_wrong:  0.000281467
Data Source:  BioPlex
STAT2
Tbio
Family:  TF
Novelty:  0.00241454
p_int:  0.996673164
p_ni:  0.000060706
p_wrong:  0.00326613
Score:  0.159
Data Source:  BioPlex,STRINGDB
CLEC11A
Tbio
Novelty:  0.03060601
p_int:  0.878935077
p_ni:  0.001029618
p_wrong:  0.120035306
Score:  0.181
Data Source:  BioPlex,STRINGDB
GDF10
Tbio
Novelty:  0.02874585
p_int:  0.777107774
p_ni:  0.000166681
p_wrong:  0.222725545
Score:  0.206
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
6
4
0
1.1
92
allergic disease
2
2
0
1.1
80.4
eosinophil count
3
2
3
76.4
serum non-albumin protein measurement
1
2
2
62.5
total blood protein measurement
1
1
1
60.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
asthma
0
1.1
92
allergic disease
0
1.1
80.4
eosinophil count
3
76.4
serum non-albumin protein measurement
2
62.5
total blood protein measurement
1
60.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 45
VGNC:1817
471091
Mouse
MGI:2447775
268882
Dog
F-box protein 45
VGNC:40784
488031
Horse
F-box protein 45
VGNC:17957
100069808
Cow
F-box protein 45
VGNC:28915
533064
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 45
Mouse
Dog
F-box protein 45
Horse
F-box protein 45
Cow
F-box protein 45
Publication Statistics
PubMed Score 25.01
PubMed score by year
PubTator Score 10.82
PubTator score by year
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Related Publications
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PMID
Year
Title