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Tbio
FBXO41
F-box only protein 41

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. This gene encodes a member of the F-box protein family, which is characterized by an approximately 40 amino acid motif, the F-box. F-box proteins constitute one of the four subunits of the SCF ubiquitin protein ligase complex that plays a role in phosphorylation-dependent ubiquitination. F-box proteins are divided into three classes depending on the interaction substrate domain each contains in addition to the F-box motif: FBXW proteins contain WD-40 domains, FBXL proteins contain leucine-rich repeats, and FBXO proteins contain either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the FBXO class. [provided by RefSeq, Feb 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295133
  • ENSP00000295133
  • ENSG00000163013
  • ENST00000520530
  • ENSP00000430968
  • ENST00000521871
  • ENSP00000428646

Symbol
  • FBX41
  • KIAA1940
  • FBX41
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.68
cellular component
0.64
tissue sample
0.61
cell line
0.55
virus perturbation
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.13   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 54   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.13   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 54   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (314)
FBXL4
Tbio
Novelty:  0.04286856
Score:  0.975
Data Source:  STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.967
Data Source:  STRINGDB
FBXL7
Tbio
Novelty:  0.10670779
Score:  0.965
Data Source:  STRINGDB
FBXW10
Tbio
Novelty:  0.11629778
Score:  0.962
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.956
Data Source:  STRINGDB
FBXO15
Tbio
Novelty:  0.08562497
Score:  0.954
Data Source:  STRINGDB
FBXW12
Tdark
Novelty:  0.27256341
Score:  0.95
Data Source:  STRINGDB
FBXO10
Tbio
Novelty:  0.18324932
Score:  0.948
Data Source:  STRINGDB
FBXO32
Tbio
Novelty:  0.00225437
Score:  0.944
Data Source:  STRINGDB
FBXO2
Tbio
Novelty:  0.01578361
Score:  0.941
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
8
3
6
67.1
self reported educational attainment
2
2
2
46.9
puberty onset measurement
1
1
1
17.3
cognitive function measurement
3
1
3
8.1
age at voice drop
1
1
1
1.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intelligence
3
6
67.1
self reported educational attainment
2
46.9
puberty onset measurement
1
17.3
cognitive function measurement
3
8.1
age at voice drop
1
1.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1261912
330369
Rat
RGD:1566130
312504
Dog
F-box protein 41
VGNC:40781
483113
Cow
F-box protein 41
VGNC:28912
536077
Pig
F-box protein 41
100517089
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
F-box protein 41
Cow
F-box protein 41
Pig
F-box protein 41
Publication Statistics
PubMed Score 5.13
PubMed score by year
PubTator Score 2.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title