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Tbio
FBXO40
F-box only protein 40

Protein Summary
Description
Probable substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex that may function in myogenesis. Members of the F-box protein family, such as FBXO40, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338040
  • ENSP00000337510
  • ENSG00000163833

Symbol
  • FBX40
  • KIAA1195
  • FBX40
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
microRNA
0.71
protein domain
0.58
cell type or tissue
0.49
cell line
0.47
tissue sample
0.47


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.4   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 114   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.4   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 114   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (330)
CUL1
Tbio
Novelty:  0.00244476
p_int:  0.99895066
p_ni:  0.00104934
Score:  0.951
Data Source:  BioPlex,STRINGDB
ACTBL2
Tbio
Novelty:  0.18080702
p_int:  0.987733545
p_ni:  0.012266455
Data Source:  BioPlex
MYO1D
Tbio
Novelty:  0.03263543
p_int:  0.975867731
p_ni:  0.024132269
Score:  0.189
Data Source:  BioPlex,STRINGDB
GSN
Tbio
Novelty:  0.00060852
p_int:  0.972192969
p_ni:  0.027807031
Score:  0.547
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.944910476
p_ni:  0.055089524
Score:  0.949
Data Source:  BioPlex,STRINGDB
FBXO9
Tbio
Novelty:  0.2145394
Score:  0.952
Data Source:  STRINGDB
ZNRF1
Tbio
Family:  Enzyme
Novelty:  0.15739853
Score:  0.948
Data Source:  STRINGDB
TRIM32
Tbio
Family:  Enzyme
Novelty:  0.00103526
Score:  0.946
Data Source:  STRINGDB
FBXO32
Tbio
Novelty:  0.00225437
Score:  0.945
Data Source:  STRINGDB
PRKN
Tbio
Family:  Enzyme
Novelty:  0.00079898
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
1
6
6
97.4
mean platelet volume
2
2
2
83
mean reticulocyte volume
1
1
1
53.3
mean corpuscular hemoglobin concentration
1
1
1
45.2
mean corpuscular volume
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
calcium measurement
6
97.4
mean platelet volume
2
83
mean reticulocyte volume
1
53.3
mean corpuscular hemoglobin concentration
1
45.2
mean corpuscular volume
1
30.2
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 40
VGNC:1816
470898
Macaque
F-box protein 40
713933
Mouse
MGI:2443753
207215
Rat
RGD:1309781
363790
Dog
F-box protein 40
VGNC:40780
488004
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 40
Macaque
F-box protein 40
Mouse
Rat
Dog
F-box protein 40
Publication Statistics
PubMed Score 5.40
PubMed score by year
PubTator Score 3.32
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title