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Tbio
FBXO4
F-box only protein 4

Protein Summary
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes ubiquitination of CCND1 and its subsequent proteasomal degradation. Recognizes TERF1 and promotes its ubiquitination together with UBE2D1. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternatively spliced transcript variants encoding different is ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281623
  • ENSP00000281623
  • ENSG00000151876
  • ENST00000296812
  • ENSP00000296812

Symbol
  • FBX4
  • FBX4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
kinase perturbation
0.81
transcription factor perturbation
0.8
transcription factor binding site profile
0.7
tissue
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.98   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 269   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.98   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 269   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 22
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (347)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999880887
p_ni:  0.000119114
Score:  0.975
Data Source:  BioPlex,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
p_int:  0.999442546
p_ni:  0.000557454
Score:  0.971
Data Source:  BioPlex,STRINGDB
AMD1
Tchem
Family:  Enzyme
Novelty:  0.00231813
p_int:  0.984035726
p_ni:  0.015964256
p_wrong:  1.8e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
DEFA1
Tbio
Novelty:  0.01027492
p_int:  0.93784647
p_ni:  0.000167616
p_wrong:  0.061985914
Score:  0.33
Data Source:  BioPlex,STRINGDB
AP1B1
Tbio
Novelty:  0.03370208
p_int:  0.925509991
p_ni:  0.074490009
Score:  0.177
Data Source:  BioPlex,STRINGDB
AP1M1
Tbio
Novelty:  0.029282
p_int:  0.879720504
p_ni:  0.120279496
Score:  0.214
Data Source:  BioPlex,STRINGDB
ESPL1
Tbio
Family:  Enzyme
Novelty:  0.00346666
p_int:  0.837844344
p_ni:  0.162155654
p_wrong:  2e-9
Score:  0.194
Data Source:  BioPlex,STRINGDB
FBXW8
Tbio
Novelty:  0.06697145
Score:  0.982
Data Source:  STRINGDB
FBXO31
Tbio
Novelty:  0.23426419
Score:  0.977
Data Source:  STRINGDB
CUL2
Tbio
Novelty:  0.00512916
Score:  0.963
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Class I MHC mediated antigen processing & presentation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (0)
No GWAS traits found
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 4
VGNC:4001
737372
Macaque
F-box protein 4
697007
Mouse
MGI:2146220
106052
Rat
RGD:1307580
310363
Dog
F-box protein 4
VGNC:40779
100856557
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 4
Macaque
F-box protein 4
Mouse
Rat
Dog
F-box protein 4
Publication Statistics
PubMed Score 14.98
PubMed score by year
PubTator Score 14.31
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title