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Tdark
FBXO34
F-box only protein 34

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Members of the F-box protein family, such as FBXO34, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313833
  • ENSP00000313159
  • ENSG00000178974
  • ENST00000440021
  • ENSP00000394117

Symbol
  • FBX34
  • Fbx34
  • CGI-301
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.91
transcription factor
0.73
tissue sample
0.65
disease perturbation
0.62
microRNA
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.79   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.79   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (33)
YEATS4
Tbio
Novelty:  0.02632024
p_int:  0.997517201
p_ni:  0.001215528
p_wrong:  0.00126727
Score:  0.196
Data Source:  BioPlex,STRINGDB
MYO6
Tbio
Novelty:  0.01073438
p_int:  0.997403298
p_ni:  0.002596702
Score:  0.826
Data Source:  BioPlex,STRINGDB
FBXO30
Tdark
Novelty:  0.60394319
p_int:  0.983580696
p_ni:  0.016419304
Score:  0.817
Data Source:  BioPlex,STRINGDB
GSN
Tbio
Novelty:  0.00060852
p_int:  0.840866919
p_ni:  0.159133081
Score:  0.811
Data Source:  BioPlex,STRINGDB
TMOD3
Tbio
Novelty:  0.04744699
p_int:  0.78943809
p_ni:  0.21056191
Score:  0.288
Data Source:  BioPlex,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
p_int:  0.77794468
p_ni:  0.22205532
Score:  0.589
Data Source:  BioPlex,STRINGDB
NEXN
Tbio
Novelty:  0.00745011
p_int:  0.771522656
p_ni:  0.000066955
p_wrong:  0.228410389
Score:  0.798
Data Source:  BioPlex,STRINGDB
FBXO36
Tdark
Novelty:  1.95826259
Score:  0.805
Data Source:  STRINGDB
FBXO16
Tdark
Novelty:  0.60353147
Score:  0.769
Data Source:  STRINGDB
FBXO28
Tbio
Novelty:  0.10548865
Score:  0.75
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (0)
No GO Terms found
Disease Associations ()
No disease associations found
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
3
4
4
97.8
galectin-3 measurement
1
2
2
96.2
blood protein measurement
1
1
1
87
eosinophil count
2
2
2
78.9
eosinophil percentage of leukocytes
1
1
1
68.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
4
97.8
galectin-3 measurement
2
96.2
blood protein measurement
1
87
eosinophil count
2
78.9
eosinophil percentage of leukocytes
1
68.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 34
VGNC:3425
452922
Macaque
F-box protein 34 [Source:HGNC Symbol;Acc:HGNC:20201]
Mouse
MGI:1926188
78938
Rat
RGD:1310108
305830
Dog
F-box protein 34
VGNC:40776
490703
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 34
Macaque
F-box protein 34 [Source:HGNC Symbol;Acc:HGNC:20201]
Mouse
Rat
Dog
F-box protein 34
Publication Statistics
PubMed Score 0.79
PubMed score by year
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Related Publications
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PMID
Year
Title