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Tbio
FBXO32
F-box only protein 32

Protein Summary
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Probably recognizes and binds to phosphorylated target proteins during skeletal muscle atrophy. Recognizes TERF1. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mic ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000443022
  • ENSP00000390790
  • ENSG00000156804
  • ENST00000517956
  • ENSP00000428205

Symbol
  • Fbx32
  • MAFbx
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.91
small molecule perturbation
0.87
transcription factor binding site profile
0.78
gene perturbation
0.75
microRNA
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.07   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 310   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 501.07   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 310   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (412)
TRIM63
Tbio
Family:  Enzyme
Novelty:  0.00384819
Score:  0.992
Data Source:  STRINGDB
FBXO21
Tbio
Novelty:  0.2186203
Score:  0.97
Data Source:  STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.968
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.96
Data Source:  STRINGDB
FBXO30
Tdark
Novelty:  0.60394319
Score:  0.952
Data Source:  STRINGDB
CDC34
Tbio
Novelty:  0.00650407
Score:  0.949
Data Source:  STRINGDB
TRIM32
Tbio
Family:  Enzyme
Novelty:  0.00103526
Score:  0.947
Data Source:  STRINGDB
UBE2S
Tbio
Novelty:  0.00363304
Score:  0.947
Data Source:  STRINGDB
FBXL4
Tbio
Novelty:  0.04286856
Score:  0.946
Data Source:  STRINGDB
FBXO40
Tbio
Novelty:  0.20308726
Score:  0.945
Data Source:  STRINGDB
Pathways (73)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
4
4
5
84.2
2
3
0
1.1
83.5
heel bone mineral density
2
2
2
57.6
electrocardiography
1
2
12
30
1
1
0
1.2
26.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
intraocular pressure measurement
5
84.2
0
1.1
83.5
heel bone mineral density
2
57.6
electrocardiography
12
30
0
1.2
26.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
F-box protein 32
704804
Mouse
MGI:1914981
67731
Rat
RGD:620373
171043
Dog
F-box protein 32
VGNC:40774
475091
Horse
F-box protein 32
VGNC:17950
100057506
Species
Name
OMA
EggNOG
Inparanoid
Macaque
F-box protein 32
Mouse
Rat
Dog
F-box protein 32
Horse
F-box protein 32
Publication Statistics
PubMed Score 501.07
PubMed score by year
PubTator Score 148.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title