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Tdark
FBXO30
F-box only protein 30

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000237281
  • ENSP00000237281
  • ENSG00000118496

Symbol
  • FBX30
  • Fbx30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
histone modification site profile
0.88
virus perturbation
0.79
microRNA
0.62
protein domain
0.58


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.77   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 41   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.77   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (308)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999998883
p_ni:  0.000001117
Score:  0.968
Data Source:  BioPlex,STRINGDB
C16orf70
Tdark
Novelty:  2.12573065
p_int:  0.990287107
p_ni:  0.009712893
Score:  0.183
Data Source:  BioPlex,STRINGDB
FBXO34
Tdark
Novelty:  5.6683456
p_int:  0.983580696
p_ni:  0.016419304
Score:  0.817
Data Source:  BioPlex,STRINGDB
PNKD
Tbio
Family:  Enzyme
Novelty:  0.02456078
p_int:  0.979182488
p_ni:  0.020817512
Data Source:  BioPlex
TNNC1
Tclin
Novelty:  0.03535727
p_int:  0.963090989
p_ni:  0.028769161
p_wrong:  0.00813985
Data Source:  BioPlex
MYO6
Tbio
Novelty:  0.01073438
p_int:  0.959105354
p_ni:  0.040894646
Score:  0.71
Data Source:  BioPlex,STRINGDB
SETDB1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00609294
p_int:  0.930878791
p_ni:  0.069121209
Score:  0.189
Data Source:  BioPlex,STRINGDB
DQX1
Tdark
Family:  Enzyme
Novelty:  1.01984582
p_int:  0.930193129
p_ni:  0.069806871
Score:  0.189
Data Source:  BioPlex,STRINGDB
BCL7C
Tdark
Novelty:  0.31203802
p_int:  0.840852286
p_ni:  0.158814881
p_wrong:  0.000332833
Data Source:  BioPlex
CUL1
Tbio
Novelty:  0.00244476
Score:  0.96
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
1
49.5
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 30
VGNC:2830
463048
Macaque
F-box protein 30
699241
Mouse
MGI:1919115
71865
Rat
RGD:1359367
308283
Dog
F-box protein 30
VGNC:40772
484023
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 30
Macaque
F-box protein 30
Mouse
Rat
Dog
F-box protein 30
Publication Statistics
PubMed Score 1.77
PubMed score by year
PubTator Score 2.20
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title