Tdark FBXO30 F-box only protein 30

Protein Summary

Description

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q8TB52
• Q9BXZ7

Gene Name

• FBXO30

Ensembl ID

• ENST00000237281
• ENSP00000237281
• ENSG00000118496

Symbol

• FBX30
• Fbx30

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.93
histone modification site profile	0.88
virus perturbation	0.79
microRNA	0.62
protein domain	0.58

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.77   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 41   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.77   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 41   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

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Expression Data (0 Tissues)

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No expression data found

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Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (308)

Explore Interacting Targets

1 – 10 of 308

• See Interactions on String-DB

SKP1

Tbio

Family:  Enzyme

Novelty:  0.00149739

p_int:  0.999998883

p_ni:  0.000001117

Score:  0.968

Data Source:  BioPlex,STRINGDB

C16orf70

Tdark

Novelty:  2.12573065

p_int:  0.990287107

p_ni:  0.009712893

Score:  0.183

Data Source:  BioPlex,STRINGDB

FBXO34

Tdark

Novelty:  5.6683456

p_int:  0.983580696

p_ni:  0.016419304

Score:  0.817

Data Source:  BioPlex,STRINGDB

PNKD

Tbio

Family:  Enzyme

Novelty:  0.02456078

p_int:  0.979182488

p_ni:  0.020817512

Data Source:  BioPlex

TNNC1

Tclin

Novelty:  0.03535727

p_int:  0.963090989

p_ni:  0.028769161

p_wrong:  0.00813985

Data Source:  BioPlex

MYO6

Tbio

Novelty:  0.01073438

p_int:  0.959105354

p_ni:  0.040894646

Score:  0.71

Data Source:  BioPlex,STRINGDB

SETDB1

Tbio

Family:  TF; Epigenetic

Novelty:  0.00609294

p_int:  0.930878791

p_ni:  0.069121209

Score:  0.189

Data Source:  BioPlex,STRINGDB

DQX1

Tdark

Family:  Enzyme

Novelty:  1.01984582

p_int:  0.930193129

p_ni:  0.069806871

Score:  0.189

Data Source:  BioPlex,STRINGDB

BCL7C

Tdark

Novelty:  0.31203802

p_int:  0.840852286

p_ni:  0.158814881

p_wrong:  0.000332833

Data Source:  BioPlex

CUL1

Tbio

Novelty:  0.00244476

Score:  0.96

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (8)

Reactome (7)

UniProt (1)

Adaptive Immune System (R-HSA-1280218)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Reactome	Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Metabolism of proteins	2050 targets	R-HSA-392499

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Antigen processing: Ubiquitination & Proteasome degradation	307 targets	R-HSA-983168
Class I MHC mediated antigen processing & presentation	437 targets	R-HSA-983169
Immune System	2246 targets	R-HSA-168256
Metabolism of proteins	2050 targets	R-HSA-392499

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (6)

Functions (3)

Components (1)

Processes (2)

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1 – 3 of 3

GO Term	Evidence	Assigned by
ubiquitin-protein transferase activity	Inferred from Experiment (EXP)	Reactome
ubiquitin protein ligase activity	Inferred from Electronic Annotation (IEA)	InterPro
zinc ion binding	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	1	1	1		49.5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	1		49.5

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Complete proteome
Metal-binding
Polymorphism
Reference proteome
Ubl conjugation
Ubl conjugation pathway
Zinc
Zinc-finger

GWAS Trait Find Similar Targets

No Header	No Header
heel bone mineral density

MGI Phenotype Find Similar Targets

No Header	No Header
mortality/aging

IDG Resources

No IDG generated resources found

Orthologs (13)

1 – 5 of 13

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	F-box protein 30	VGNC:2830	463048
Macaque	F-box protein 30		699241
Mouse	F-box protein 30	MGI:1919115	71865
Rat	F-box protein 30	RGD:1359367	308283
Dog	F-box protein 30	VGNC:40772	484023

Species	Name	OMA	EggNOG	Inparanoid
Chimp	F-box protein 30
Macaque	F-box protein 30
Mouse	F-box protein 30
Rat	F-box protein 30
Dog	F-box protein 30

Publication Statistics

PubMed Score 1.77

PubMed score by year

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PubTator Score 2.20

PubTator score by year

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Related Publications

Text Mined References (9)

GeneRif Annotations (1)

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PMID	Year	Title