Protein Summary
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Required for muscle atrophy following denervation. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and it is upregulated in nasopharyngeal carcinoma. [provided by RefSeq, Jul 2008]
- ENST00000237281
- ENSP00000237281
- ENSG00000118496
- FBX30
- Fbx30
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
kinase perturbation | 0.93 | ||
histone modification site profile | 0.88 | ||
virus perturbation | 0.79 | ||
microRNA | 0.62 | ||
protein domain | 0.58 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.77 (req: < 5)
Gene RIFs: 1 (req: <= 3)
Antibodies: 41 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1.77 (req: >= 5)
Gene RIFs: 1 (req: > 3)
Antibodies: 41 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (308)
SKP1
Family: Enzyme
Novelty: 0.00149739
p_int: 0.999998883
p_ni: 0.000001117
Score: 0.968
Data Source: BioPlex,STRINGDB
C16orf70
Novelty: 2.12573065
p_int: 0.990287107
p_ni: 0.009712893
Score: 0.183
Data Source: BioPlex,STRINGDB
FBXO34
Novelty: 5.6683456
p_int: 0.983580696
p_ni: 0.016419304
Score: 0.817
Data Source: BioPlex,STRINGDB
PNKD
Family: Enzyme
Novelty: 0.02456078
p_int: 0.979182488
p_ni: 0.020817512
Data Source: BioPlex
TNNC1
Novelty: 0.03535727
p_int: 0.963090989
p_ni: 0.028769161
p_wrong: 0.00813985
Data Source: BioPlex
MYO6
Novelty: 0.01073438
p_int: 0.959105354
p_ni: 0.040894646
Score: 0.71
Data Source: BioPlex,STRINGDB
SETDB1
Family: TF; Epigenetic
Novelty: 0.00609294
p_int: 0.930878791
p_ni: 0.069121209
Score: 0.189
Data Source: BioPlex,STRINGDB
DQX1
Family: Enzyme
Novelty: 1.01984582
p_int: 0.930193129
p_ni: 0.069806871
Score: 0.189
Data Source: BioPlex,STRINGDB
BCL7C
Novelty: 0.31203802
p_int: 0.840852286
p_ni: 0.158814881
p_wrong: 0.000332833
Data Source: BioPlex
Nearest Tclin Targets
Pathways (8)
Reactome (7)
UniProt (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Adaptive Immune System | ||||
Reactome | Antigen processing: Ubiquitination & Proteasome degradation | ||||
Reactome | Class I MHC mediated antigen processing & presentation | ||||
Reactome | Immune System | ||||
Reactome | Metabolism of proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Adaptive Immune System | ||||
Antigen processing: Ubiquitination & Proteasome degradation | ||||
Class I MHC mediated antigen processing & presentation | ||||
Immune System | ||||
Metabolism of proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (6)
Functions (3)
Components (1)
Processes (2)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 1 | 1 | 1 | 49.5 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 1 | 49.5 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | F-box protein 30 | VGNC:2830 | 463048 | |||||
Macaque | F-box protein 30 | 699241 | ||||||
Mouse | MGI:1919115 | 71865 | ||||||
Rat | RGD:1359367 | 308283 | ||||||
Dog | F-box protein 30 | VGNC:40772 | 484023 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | F-box protein 30 | |||||
Macaque | F-box protein 30 | |||||
Mouse | ||||||
Rat | ||||||
Dog | F-box protein 30 | |||||
Publication Statistics
PubMed Score 1.77
PubMed score by year
PubTator Score 2.20
PubTator score by year
Related Publications
Text Mined References (9)
GeneRif Annotations (1)
Items per page:
0 of 0
PMID | Year | Title |
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