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Tbio
FBXO3
F-box only protein 3

Protein Summary
Description
Substrate recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the ubiquitination of HIPK2 and probably that of EP300, leading to rapid degradation by the proteasome. In the presence of PML, HIPK2 ubiquitination still occurs, but degradation is prevented. PML, HIPK2 and FBXO3 may act synergically to activate p53/TP53-dependent transactivation. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265651
  • ENSP00000265651
  • ENSG00000110429
  • ENST00000448981
  • ENSP00000408836
  • ENST00000530401
  • ENSP00000433781

Symbol
  • FBX3
  • FBA
  • FBX3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
0.83
histone modification site profile
0.77
microRNA
0.73
cell line
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.05   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 128   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.05   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 128   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (54)
CALHM4
Tdark
Family:  IC
Novelty:  2.79788039
p_int:  0.999989253
p_ni:  0.000010448
p_wrong:  2.99e-7
Data Source:  BioPlex
ATG9B
Tbio
p_int:  0.999878642
p_ni:  0.00000453
p_wrong:  0.000116828
Data Source:  BioPlex
PLCD1
Tchem
Family:  Enzyme
Novelty:  0.00742197
p_int:  0.999849887
p_ni:  0.000149478
p_wrong:  6.36e-7
Data Source:  BioPlex
DSG4
Tbio
Novelty:  0.01599371
p_int:  0.999808213
p_ni:  0.000191778
p_wrong:  1e-8
Data Source:  BioPlex
HEPHL1
Tbio
Novelty:  0.44678065
p_int:  0.999718718
p_ni:  0.000281281
p_wrong:  1e-9
Data Source:  BioPlex
TRIM29
Tbio
Novelty:  0.02572789
p_int:  0.998142209
p_ni:  0.001857567
p_wrong:  2.23e-7
Data Source:  BioPlex
VSIG8
Tdark
Novelty:  1.16023405
p_int:  0.996275674
p_ni:  0.003159355
p_wrong:  0.000564971
Data Source:  BioPlex
S100A3
Tbio
Novelty:  0.03024004
p_int:  0.995343336
p_ni:  0.000087026
p_wrong:  0.004569638
Data Source:  BioPlex
LRRC15
Tbio
Novelty:  0.03701624
p_int:  0.977158502
p_ni:  0.022841498
Data Source:  BioPlex
DUSP14
Tbio
Family:  Enzyme
Novelty:  0.04013065
p_int:  0.965103839
p_ni:  0.034884992
p_wrong:  0.000011169
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
2
1
1
1.1
40.3
comparative body size at age 10, self-reported
1
1
1
28.1
biological sex
1
1
1
24.5
diet measurement
1
1
1
11
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1.1
40.3
comparative body size at age 10, self-reported
1
28.1
biological sex
1
24.5
diet measurement
1
11
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 3
VGNC:3278
451112
Macaque
F-box protein 3
693281
Mouse
MGI:1929084
57443
Rat
RGD:1593433
690634
Dog
F-box protein 3
VGNC:40771
475944
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 3
Macaque
F-box protein 3
Mouse
Rat
Dog
F-box protein 3
Publication Statistics
PubMed Score 62.05
PubMed score by year
PubTator Score 15.74
PubTator score by year
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Related Publications
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PMID
Year
Title