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Tbio
FBXO28
F-box only protein 28

Protein Summary
Description
Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. Members of the F-box protein family, such as FBXO28, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366862
  • ENSP00000355827
  • ENSG00000143756
  • ENST00000424254
  • ENSP00000416888

Symbol
  • CENP-30
  • KIAA0483
  • Fbx28
  • CENP-30
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (protein) perturbation
0.99
microRNA
0.9
virus perturbation
0.85
transcription factor binding site profile
0.74
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.04   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 173   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.04   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 173   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (99)
EML1
Tbio
Novelty:  0.02262549
p_int:  1
Score:  0.263
Data Source:  BioPlex,STRINGDB
ARHGEF6
Tbio
Novelty:  0.02162737
p_int:  0.999999986
p_ni:  1.4e-8
Score:  0.791
Data Source:  BioPlex,STRINGDB
TRAF1
Tbio
Novelty:  0.00526776
p_int:  0.999999272
p_ni:  7.28e-7
Score:  0.217
Data Source:  BioPlex,STRINGDB
ARHGEF7
Tbio
Novelty:  0.00919946
p_int:  0.99999878
p_ni:  0.00000122
Score:  0.647
Data Source:  BioPlex,STRINGDB
HOMER1
Tbio
Novelty:  0.00264721
p_int:  0.999995823
p_ni:  0.000004177
Score:  0.179
Data Source:  BioPlex,STRINGDB
TMCC3
Tdark
Novelty:  0.67741343
p_int:  0.999993816
p_ni:  0.00000458
p_wrong:  0.000001605
Score:  0.647
Data Source:  BioPlex,STRINGDB
TCP10L
Tbio
Novelty:  0.24089479
p_int:  0.999983914
p_ni:  0.000016086
Data Source:  BioPlex
CLEC11A
Tbio
Novelty:  0.03060601
p_int:  0.999983533
p_ni:  0.000016466
p_wrong:  1e-9
Data Source:  BioPlex
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999974903
p_ni:  0.000025097
Score:  0.725
Data Source:  BioPlex,STRINGDB
LURAP1L
Tdark
Novelty:  2.32630524
p_int:  0.999974142
p_ni:  0.000025858
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ceramide measurement
5
3
5
92.2
mean platelet volume
2
2
2
62
sphingomyelin measurement
2
3
3
48.8
mean corpuscular volume
1
1
1
13.3
red blood cell density measurement
1
1
1
9.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
ceramide measurement
5
92.2
mean platelet volume
2
62
sphingomyelin measurement
3
48.8
mean corpuscular volume
1
13.3
red blood cell density measurement
1
9.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 28
VGNC:1239
735792
Macaque
F-box protein 28
702246
Mouse
MGI:1261890
67948
Rat
RGD:1304584
305105
Dog
F-box protein 28
VGNC:40770
612012
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 28
Macaque
F-box protein 28
Mouse
Rat
Dog
F-box protein 28
Publication Statistics
PubMed Score 11.04
PubMed score by year
PubTator Score 7.42
PubTator score by year
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Related Publications
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PMID
Year
Title