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Tdark
FBXO27
F-box only protein 27

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Able to recognize and bind denatured glycoproteins, which are modified with complex-type oligosaccharides. Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000292853
  • ENSP00000292853
  • ENSG00000161243
  • ENST00000509137
  • ENSP00000437662
  • ENST00000635475
  • ENSP00000489487
  • ENSG00000283021
  • ENST00000635513
  • ENSP00000489017

Symbol
  • FBG5
  • FBX27
  • FBG5
  • Fbx27
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.71
transcription factor binding site profile
0.63
histone modification site profile
0.62
cell type or tissue
0.6
virus perturbation
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.82   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.82   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (318)
CLU
Tbio
Novelty:  0.00054776
p_int:  0.999641451
p_ni:  0.000008264
p_wrong:  0.000350285
Score:  0.187
Data Source:  BioPlex,STRINGDB
NELL1
Tbio
Family:  Enzyme
Novelty:  0.01325888
p_int:  0.999404635
p_ni:  0.000008366
p_wrong:  0.000586999
Score:  0.209
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.991
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.969
Data Source:  STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.953
Data Source:  STRINGDB
FBXW5
Tbio
Novelty:  0.13100873
Score:  0.953
Data Source:  STRINGDB
FBXO4
Tbio
Novelty:  0.06891705
Score:  0.945
Data Source:  STRINGDB
FBXL14
Tbio
Novelty:  0.21211079
Score:  0.945
Data Source:  STRINGDB
FBXL5
Tbio
Novelty:  0.03103624
Score:  0.94
Data Source:  STRINGDB
STUB1
Tbio
Family:  Enzyme
Novelty:  0.00055102
Score:  0.932
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
1
1
49.7
serum gamma-glutamyl transferase measurement
1
1
1
39.7
intelligence
1
1
0
5.5
34.5
body weight
1
1
1
2.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
diastolic blood pressure
1
49.7
serum gamma-glutamyl transferase measurement
1
39.7
intelligence
0
5.5
34.5
body weight
1
2.5
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 27
VGNC:11052
104003377
Macaque
F-box protein 27
695939
Mouse
MGI:2685007
233040
Dog
F-box protein 27
VGNC:40769
484515
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 27
Macaque
F-box protein 27
Mouse
Dog
F-box protein 27
Publication Statistics
PubMed Score 4.82
PubMed score by year
PubTator Score 4.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title