You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FBXO21
F-box only protein 21

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000330622
  • ENSP00000328187
  • ENSG00000135108
  • ENST00000622495
  • ENSP00000483508

Symbol
  • FBX21
  • KIAA0875
  • FBX21
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
transcription factor perturbation
0.98
virus perturbation
0.79
histone modification site profile
0.67
transcription factor binding site profile
0.67


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.36   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.36   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (322)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999921257
p_ni:  0.000078743
Score:  0.973
Data Source:  BioPlex,STRINGDB
PRTN3
Tchem
Family:  Enzyme
Novelty:  0.00022728
p_int:  0.999767895
p_ni:  0.000232105
Data Source:  BioPlex
IDS
Tbio
Family:  Enzyme
Novelty:  0.00733996
p_int:  0.999451149
p_ni:  0.000548847
p_wrong:  4e-9
Score:  0.175
Data Source:  BioPlex,STRINGDB
EID1
Tbio
Novelty:  0.02414732
p_int:  0.999249417
p_ni:  0.000750581
p_wrong:  1e-9
Score:  0.576
Data Source:  BioPlex,STRINGDB
KERA
Tbio
Novelty:  0.00789599
p_int:  0.996756472
p_ni:  0.003243528
Score:  0.188
Data Source:  BioPlex,STRINGDB
SGSH
Tbio
Family:  Enzyme
Novelty:  0.00670111
p_int:  0.964534675
p_ni:  0.035465319
p_wrong:  6e-9
Data Source:  BioPlex
FBLN2
Tbio
Novelty:  0.01340024
p_int:  0.924359469
p_ni:  0.075640531
Score:  0.155
Data Source:  BioPlex,STRINGDB
ARSG
Tbio
Family:  Enzyme
Novelty:  0.04412917
p_int:  0.922976179
p_ni:  0.077004057
p_wrong:  0.000019764
Score:  0.163
Data Source:  BioPlex,STRINGDB
ARSE
Tbio
Family:  Enzyme
Novelty:  0.00151862
p_int:  0.904624527
p_ni:  0.095375454
p_wrong:  1.9e-8
Data Source:  BioPlex
VWCE
Tbio
Novelty:  0.09328341
p_int:  0.801700424
p_ni:  0.198299566
p_wrong:  1e-8
Score:  0.151
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
4
2
2
6.1
86.3
depressive symptom measurement
2
2
2
83.3
hematocrit
3
3
3
76.3
wellbeing measurement
3
1
3
73.4
hemoglobin measurement
3
3
3
70.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neuroticism measurement
2
6.1
86.3
depressive symptom measurement
2
83.3
hematocrit
3
76.3
wellbeing measurement
3
73.4
hemoglobin measurement
3
70.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 21
VGNC:5378
452287
Macaque
F-box protein 21
693647
Mouse
MGI:1924223
231670
Rat
RGD:1307346
360818
Dog
F-box protein 21
VGNC:40766
486290
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 21
Macaque
F-box protein 21
Mouse
Rat
Dog
F-box protein 21
Publication Statistics
PubMed Score 6.36
PubMed score by year
PubTator Score 2.28
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title