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Tbio
FBXO15
F-box only protein 15

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Members of the F-box protein family, such as FBXO15, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000419743
  • ENSP00000393154
  • ENSG00000141665

Symbol
  • FBX15
  • FBX15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.87
PubMedID
0.66
cell type or tissue
0.62
tissue sample
0.57
transcription factor
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.64   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 196   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.64   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 196   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (342)
CPA6
Tbio
Family:  Enzyme
Novelty:  0.05034597
p_int:  0.999770249
p_ni:  0.000012594
p_wrong:  0.000217157
Score:  0.537
Data Source:  BioPlex,STRINGDB
HINT3
Tdark
Novelty:  1.14285714
p_int:  0.998701103
p_ni:  0.000001505
p_wrong:  0.001297392
Score:  0.485
Data Source:  BioPlex,STRINGDB
HSPD1
Tbio
Novelty:  0.00018924
p_int:  0.866775674
p_ni:  0.133224326
Data Source:  BioPlex
FBXL4
Tbio
Novelty:  0.04286856
Score:  0.957
Data Source:  STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
Score:  0.955
Data Source:  STRINGDB
FBXO41
Tbio
Novelty:  0.19719067
Score:  0.954
Data Source:  STRINGDB
FBXO21
Tbio
Novelty:  0.2186203
Score:  0.95
Data Source:  STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.948
Data Source:  STRINGDB
FBXW10
Tbio
Novelty:  0.11629778
Score:  0.94
Data Source:  STRINGDB
UBA7
Tbio
Novelty:  0.01923008
Score:  0.935
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
1
2
2
55.5
17-hydroxyprogesterone measurement
1
1
1
10.3
sleep measurement
1
1
1
6.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
2
55.5
17-hydroxyprogesterone measurement
1
10.3
sleep measurement
1
6.9
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 15
VGNC:13260
455471
Macaque
F-box protein 15
694446
Mouse
MGI:1354755
50764
Rat
RGD:1310628
361354
Dog
F-box protein 15
VGNC:40763
100685224
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 15
Macaque
F-box protein 15
Mouse
Rat
Dog
F-box protein 15
Publication Statistics
PubMed Score 11.64
PubMed score by year
PubTator Score 1.30
PubTator score by year
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Related Publications
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0 of 0
PMID
Year
Title