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Tbio
FBXO10
F-box only protein 10

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The SCF(FBXO10) complex mediates ubiquitination and degradation of BCL2, an antiapoptotic protein, thereby playing a role in apoptosis by controlling the stability of BCL2. Members of the F-box protein family, such as FBXO10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000432825
  • ENSP00000403802
  • ENSG00000147912

Symbol
  • FBX10
  • PRMT11
  • FBX10
  • PRMT11
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
histone modification site profile
0.64
tissue sample
0.59
cell type or tissue
0.58
microRNA
0.55


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.6   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 57   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.6   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 57   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (346)
AJUBA
Tbio
Novelty:  0.03561829
p_int:  0.999999279
p_ni:  7.21e-7
Data Source:  BioPlex
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.99999906
p_ni:  9.4e-7
Score:  0.967
Data Source:  BioPlex,STRINGDB
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.999996866
p_ni:  0.000003134
Data Source:  BioPlex
FAM219A
Tdark
Novelty:  12.35294118
p_int:  0.999977517
p_ni:  0.000022483
Score:  0.227
Data Source:  BioPlex,STRINGDB
NECTIN4
Tclin
Novelty:  0.00694563
p_int:  0.999902062
p_ni:  0.000097938
Score:  0.243
Data Source:  BioPlex,STRINGDB
SYCE1
Tbio
Novelty:  0.05038876
p_int:  0.999883584
p_ni:  0.000116416
Data Source:  BioPlex
LARP4
Tbio
Novelty:  0.08499175
p_int:  0.999482453
p_ni:  0.000517533
p_wrong:  1.4e-8
Data Source:  BioPlex
LIMD1
Tbio
Novelty:  0.04868333
p_int:  0.999470086
p_ni:  0.000529875
p_wrong:  4e-8
Data Source:  BioPlex
TPCN2
Tchem
Family:  IC
Novelty:  0.01351129
p_int:  0.99694949
p_ni:  0.002653057
p_wrong:  0.000397453
Data Source:  BioPlex
ARL15
Tbio
Family:  Enzyme
Novelty:  0.09327102
p_int:  0.996700094
p_ni:  0.002787282
p_wrong:  0.000512624
Score:  0.237
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein-associated phospholipase A(2) measurement
1
1
0
32.5
24.5
daytime rest measurement
1
1
1
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lipoprotein-associated phospholipase A(2) measurement
0
32.5
24.5
daytime rest measurement
1
24.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box protein 10
VGNC:4731
465102
Macaque
F-box protein 10
718443
Mouse
MGI:2686937
269529
Rat
RGD:1305465
362511
Dog
F-box protein 10
VGNC:51718
481613
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box protein 10
Macaque
F-box protein 10
Mouse
Rat
Dog
F-box protein 10
Publication Statistics
PubMed Score 7.60
PubMed score by year
PubTator Score 3.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title