You are using an outdated browser. Please upgrade your browser to improve your experience.

Tdark
FBXL8
F-box/LRR-repeat protein 8

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class. It shares 78% sequence identity with the mouse protein. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258200
  • ENSP00000258200
  • ENSG00000135722
  • ENST00000519917
  • ENSP00000430490

Symbol
  • FBL8
  • FBL8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.71
tissue sample
0.67
cell type or tissue
0.58
gene perturbation
0.58
cell line
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.55   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 145   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.55   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 145   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (302)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999999997
p_ni:  2e-9
p_wrong:  1e-9
Score:  0.963
Data Source:  BioPlex,STRINGDB
SNAI1
Tbio
Family:  TF
Novelty:  0.00040495
p_int:  0.756315906
p_ni:  8.7e-8
p_wrong:  0.243684008
Score:  0.622
Data Source:  BioPlex,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.956
Data Source:  STRINGDB
FBXL22
Tdark
Novelty:  0.59436124
Score:  0.949
Data Source:  STRINGDB
FBXL16
Tdark
Novelty:  0.96762375
Score:  0.946
Data Source:  STRINGDB
FBXL7
Tbio
Novelty:  0.10670779
Score:  0.945
Data Source:  STRINGDB
FBXL13
Tdark
Novelty:  0.33362589
Score:  0.942
Data Source:  STRINGDB
FBXL20
Tbio
Novelty:  0.092544
Score:  0.94
Data Source:  STRINGDB
KLHL25
Tbio
Novelty:  0.14475787
Score:  0.927
Data Source:  STRINGDB
KLHL13
Tdark
Novelty:  0.23576387
Score:  0.92
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
1
4
4
96.2
mean reticulocyte volume
1
4
4
94.2
heel bone mineral density
1
1
1
78.4
high density lipoprotein cholesterol measurement
2
3
3
71.8
balding measurement
1
1
1
38.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular volume
4
96.2
mean reticulocyte volume
4
94.2
heel bone mineral density
1
78.4
high density lipoprotein cholesterol measurement
3
71.8
balding measurement
1
38.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 8
454155
Mouse
MGI:1354697
50788
Rat
RGD:1566420
498941
Dog
F-box and leucine rich repeat protein 8
611261
Cow
F-box and leucine rich repeat protein 8
614765
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 8
Mouse
Rat
Dog
F-box and leucine rich repeat protein 8
Cow
F-box and leucine rich repeat protein 8
Publication Statistics
PubMed Score 1.55
PubMed score by year
PubTator Score 0.10
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title