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Tbio
FBXL5
F-box/LRR-repeat protein 5

Protein Summary
Description
Component of some SCF (SKP1-cullin-F-box) protein ligase complex that plays a central role in iron homeostasis by promoting the ubiquitination and subsequent degradation of IREB2/IRP2. Upon high iron and oxygen level, it specifically recognizes and binds IREB2/IRP2, promoting its ubiquitination and degradation by the proteasome. Promotes ubiquitination and subsequent degradation of DCTN1/p150-glued. This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000341285
  • ENSP00000344866
  • ENSG00000118564
  • ENST00000412094
  • ENSP00000408679

Symbol
  • FBL4
  • FBL5
  • FLR1
  • FBL4
  • FBL5
  • FLR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
microRNA
0.7
tissue sample
0.69
histone modification site profile
0.66
transcription factor binding site profile
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.4   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.4   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (368)
NEURL4
Tdark
Novelty:  0.20430708
p_int:  0.999990898
p_ni:  0.000009102
Score:  0.504
Data Source:  BioPlex,STRINGDB
HERC2
Tbio
Family:  Enzyme
Novelty:  0.06552683
p_int:  0.999948723
p_ni:  0.000051277
Score:  0.95
Data Source:  BioPlex,STRINGDB
ZNF106
Tbio
Novelty:  0.17021565
p_int:  0.99993837
p_ni:  0.00006163
Score:  0.214
Data Source:  BioPlex,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
p_int:  0.998777197
p_ni:  0.001222803
Score:  0.971
Data Source:  BioPlex,Reactome,STRINGDB
ECI2
Tbio
Family:  Enzyme
Novelty:  0.02317646
p_int:  0.997712257
p_ni:  0.002287743
Data Source:  BioPlex
MAP7D1
Tdark
Novelty:  0.43190333
p_int:  0.996226217
p_ni:  0.003773783
Data Source:  BioPlex
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.988900879
p_ni:  0.011099121
Score:  0.952
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.978614436
p_ni:  0.021385564
Score:  0.974
Data Source:  BioPlex,Reactome,STRINGDB
APPBP2
Tbio
Novelty:  0.14742368
p_int:  0.966191741
p_ni:  0.033806935
p_wrong:  0.000001325
Score:  0.207
Data Source:  BioPlex,STRINGDB
CENPF
Tbio
Novelty:  0.00676983
p_int:  0.96394154
p_ni:  0.03605846
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (13)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
Chaperonin-mediated protein folding
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Association of TriC/CCT with target proteins during biosynthesis
Chaperonin-mediated protein folding
Class I MHC mediated antigen processing & presentation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
4
1
1.1
88.1
mean corpuscular hemoglobin concentration
1
1
1
85.3
red blood cell density measurement
1
1
1
78.6
mean corpuscular volume
2
1
2
76.9
mean reticulocyte volume
1
1
1
61
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1.1
88.1
mean corpuscular hemoglobin concentration
1
85.3
red blood cell density measurement
1
78.6
mean corpuscular volume
2
76.9
mean reticulocyte volume
1
61
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 5
VGNC:2990
461125
Macaque
F-box and leucine rich repeat protein 5
722846
Mouse
MGI:2152883
242960
Rat
RGD:1306887
305424
Dog
F-box and leucine rich repeat protein 5
VGNC:40761
479085
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 5
Macaque
F-box and leucine rich repeat protein 5
Mouse
Rat
Dog
F-box and leucine rich repeat protein 5
Publication Statistics
PubMed Score 43.40
PubMed score by year
PubTator Score 18.81
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title