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Tbio
FBXL19
F-box/LRR-repeat protein 19

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. This gene encodes a member of the Skp1-Cullin-F-box family of E3 ubiquitin ligases. The encoded protein is reported to bind to the transmembrane receptor interleukin 1 receptor-like 1 and regulate its ubiquitination and degradation. This protein has been linked to the regulation of pulmonary inflammation and psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380310
  • ENSP00000369666
  • ENSG00000099364

Symbol
  • FBL19
  • Fbl19
  • CXXC11
  • JHDM1C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
transcription factor binding site profile
0.82
transcription factor
0.79
tissue sample
0.7
histone modification site profile
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.82   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.82   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (497)
MED21
Tbio
Family:  Enzyme
Novelty:  0.06996616
p_int:  0.999997398
p_ni:  0.0000026
p_wrong:  3e-9
Score:  0.178
Data Source:  BioPlex,STRINGDB
DENND2D
Tbio
Novelty:  0.16496649
p_int:  0.99998952
p_ni:  0.00001045
p_wrong:  3e-8
Score:  0.217
Data Source:  BioPlex,STRINGDB
INPP5K
Tbio
Family:  Enzyme
Novelty:  0.07282504
p_int:  0.999464794
p_ni:  0.000535206
Data Source:  BioPlex
MED17
Tbio
Family:  Enzyme
Novelty:  0.02984503
p_int:  0.999010894
p_ni:  0.000989105
p_wrong:  1e-9
Score:  0.164
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.998918007
p_ni:  0.001081993
Score:  0.994
Data Source:  BioPlex,STRINGDB
PLCD4
Tbio
Family:  Enzyme
Novelty:  0.07014141
p_int:  0.997945306
p_ni:  0.002054481
p_wrong:  2.12e-7
Data Source:  BioPlex
MED10
Tdark
Family:  Enzyme
Novelty:  0.02988632
p_int:  0.995335235
p_ni:  0.004663051
p_wrong:  0.000001714
Data Source:  BioPlex
MED20
Tbio
Family:  Enzyme
Novelty:  0.02039559
p_int:  0.988997833
p_ni:  0.011001534
p_wrong:  6.33e-7
Data Source:  BioPlex
NOL11
Tbio
Novelty:  0.47253767
p_int:  0.983608711
p_ni:  0.016391289
Data Source:  BioPlex
PSME3
Tbio
Novelty:  0.01051254
p_int:  0.962399666
p_ni:  0.037600239
p_wrong:  9.6e-8
Score:  0.179
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (31)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
4
0
1.2
83.8
mean reticulocyte volume
1
1
1
82.8
mean corpuscular volume
1
1
1
82.2
serum non-albumin protein measurement
1
1
1
71.3
triglyceride measurement
2
2
1
2.1
68.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
83.8
mean reticulocyte volume
1
82.8
mean corpuscular volume
1
82.2
serum non-albumin protein measurement
1
71.3
triglyceride measurement
1
2.1
68.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:3039600
233902
Rat
RGD:1310989
308999
Dog
F-box and leucine rich repeat protein 19
VGNC:40759
100856520
Horse
F-box and leucine rich repeat protein 19
VGNC:17938
100063588
Cow
F-box/LRR-repeat protein 19
540981
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
F-box and leucine rich repeat protein 19
Horse
F-box and leucine rich repeat protein 19
Cow
F-box/LRR-repeat protein 19
Publication Statistics
PubMed Score 15.82
PubMed score by year
PubTator Score 3.39
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title