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Tdark
FBXL18
F-box/LRR-repeat protein 18

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. The protein encoded by this gene is a member of a family of proteins that contain an approximately 40-amino acid F-box motif. This motif is important for interaction with SKP1 and for targeting some proteins for degradation. The encoded protein has been shown to control the cellular level of FBXL7, a protein that induces mitotic arrest, by targeting it for polyubiquitylation and proteasomal degradation. Members of the F-box protein family, such as FBXL18, are characterized by an approximately 40-amino acid F-box motif. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains. [provided by RefSeq, Mar 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000382368
  • ENSP00000371805
  • ENSG00000155034
  • ENST00000415009
  • ENSP00000415064
  • ENST00000453700
  • ENSP00000444797

Symbol
  • FBL18
  • Fbl18
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor binding site profile
0.84
transcription factor perturbation
0.8
virus perturbation
0.79
kinase perturbation
0.71


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.53   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 88   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.53   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 88   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (317)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999999955
p_ni:  4.5e-8
Score:  0.956
Data Source:  BioPlex,Reactome,STRINGDB
MAGEA1
Tbio
Novelty:  0.00506874
p_int:  0.999947311
p_ni:  0.000052689
Data Source:  BioPlex
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.99993134
p_ni:  0.000068474
p_wrong:  1.86e-7
Data Source:  BioPlex
IRGC
Tbio
Family:  Enzyme
Novelty:  0.10743948
p_int:  0.999727821
p_ni:  0.000272173
p_wrong:  6e-9
Score:  0.19
Data Source:  BioPlex,STRINGDB
MOCS3
Tbio
Family:  Enzyme
Novelty:  0.039209
p_int:  0.999566692
p_ni:  0.000433301
p_wrong:  7e-9
Score:  0.188
Data Source:  BioPlex,STRINGDB
LYPD4
Tbio
Novelty:  0.00381728
p_int:  0.99776622
p_ni:  0.002165208
p_wrong:  0.000068572
Data Source:  BioPlex
FBXL16
Tdark
Novelty:  0.96762375
p_int:  0.933691494
p_ni:  0.014208879
p_wrong:  0.052099627
Score:  0.964
Data Source:  BioPlex,STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
p_int:  0.931532405
p_ni:  0.025037505
p_wrong:  0.04343009
Score:  0.931
Data Source:  BioPlex,STRINGDB
TBL1Y
Tbio
p_int:  0.841210213
p_ni:  0.016096314
p_wrong:  0.142693473
Data Source:  BioPlex
FBXL3
Tbio
Novelty:  0.05042679
Score:  0.97
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (12)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Class I MHC mediated antigen processing & presentation
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Cell Cycle
Cell Cycle, Mitotic
Class I MHC mediated antigen processing & presentation
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
2
2
68.5
reticulocyte measurement
2
2
2
67.5
reticulocyte count
2
2
2
63.6
monocyte percentage of leukocytes
1
1
1
57.3
lymphocyte count
2
2
2
56.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
2
68.5
reticulocyte measurement
2
67.5
reticulocyte count
2
63.6
monocyte percentage of leukocytes
1
57.3
lymphocyte count
2
56.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 18
VGNC:4355
463246
Macaque
F-box and leucine rich repeat protein 18
716863
Mouse
MGI:2444450
231863
Rat
RGD:1596958
678726
Dog
F-box and leucine rich repeat protein 18
VGNC:54024
489881
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 18
Macaque
F-box and leucine rich repeat protein 18
Mouse
Rat
Dog
F-box and leucine rich repeat protein 18
Publication Statistics
PubMed Score 3.53
PubMed score by year
PubTator Score 1.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title