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Tbio
FBXL17
F-box/LRR-repeat protein 17

Protein Summary
Description
Substrate-recognition component of the SCF(FBXL17) E3 ubiquitin ligase complex, a key component of a quality control pathway required to ensure functional dimerization of BTB domain-containing proteins (dimerization quality control, DQC) (PubMed:30190310). FBXL17 specifically recognizes and binds a conserved degron of non-consecutive residues present at the interface of BTB dimers of aberrant composition: aberrant BTB dimer are then ubiquitinated by the SCF(FBXL17) complex and degraded by the proteaseome (PubMed:30190310). The ability of the SCF(FBXL17) complex to eliminate compromised BTB dimers is required for the differentiation and survival of neural crest and neuronal cells (By similarity). The SCF(FBXL17) complex mediates ubiquitination and degradation of BACH1 (PubMed:24035498, PubMed:30190310). The SCF(FBXL17) complex is also involved in the regulation of the hedgehog/smoothened (Hh) signaling pathway by mediating the ubiquitination and degradation of SUFU, allowing the release ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359660
  • ENSP00000352683
  • ENSG00000145743
  • ENST00000496714
  • ENSP00000418111
  • ENST00000542267
  • ENSP00000437464

Symbol
  • FBL17
  • FBX13
  • FBXO13
  • Fbl17
  • Fbx13
  • FBXO13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
transcription factor binding site profile
0.8
histone modification site profile
0.69
cell line
0.63
phenotype
0.63


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.2   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 117   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.2   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 117   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (64)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.999999826
p_ni:  1.68e-7
p_wrong:  5e-9
Score:  0.834
Data Source:  BioPlex,STRINGDB
ZBTB42
Tbio
Family:  TF
Novelty:  0.54038505
p_int:  0.999999656
p_ni:  3.44e-7
Score:  0.221
Data Source:  BioPlex,STRINGDB
KLHL28
Tdark
Novelty:  1.1777024
p_int:  0.999997445
p_ni:  0.000002549
p_wrong:  6e-9
Score:  0.579
Data Source:  BioPlex,STRINGDB
KLHL2
Tbio
Novelty:  0.07279226
p_int:  0.999996476
p_ni:  0.000003523
p_wrong:  1e-9
Score:  0.204
Data Source:  BioPlex,STRINGDB
KLHL9
Tdark
Novelty:  0.22434722
p_int:  0.999977773
p_ni:  0.00002222
p_wrong:  7e-9
Data Source:  BioPlex
KBTBD7
Tdark
Novelty:  0.4947466
p_int:  0.9999478
p_ni:  0.000052197
p_wrong:  3e-9
Data Source:  BioPlex
BACH1
Tbio
Family:  TF
Novelty:  0.04011328
p_int:  0.99993976
p_ni:  0.000060231
p_wrong:  9e-9
Score:  0.369
Data Source:  BioPlex,STRINGDB
KLHL20
Tbio
Novelty:  0.12205871
p_int:  0.999877317
p_ni:  0.000122679
p_wrong:  3e-9
Score:  0.154
Data Source:  BioPlex,STRINGDB
ZBTB46
Tbio
Family:  TF
Novelty:  0.04699856
p_int:  0.999839343
p_ni:  0.00016065
p_wrong:  7e-9
Score:  0.205
Data Source:  BioPlex,STRINGDB
KLHL14
Tbio
Novelty:  0.1214402
p_int:  0.998933283
p_ni:  0.000737941
p_wrong:  0.000328776
Score:  0.697
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (132)
Find Similar Targets
Items per page:
1 – 5 of 132
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
Hedgehog Signaling Pathway
WikiPathways
Hedgehog Signaling Pathway
WikiPathways
Hedgehog Signaling Pathway
WikiPathways
Hedgehog Signaling Pathway
WikiPathways
Hedgehog Signaling Pathway
Name
Explore in Pharos
Explore in Source
Hedgehog Signaling Pathway
Hedgehog Signaling Pathway
Hedgehog Signaling Pathway
Hedgehog Signaling Pathway
Hedgehog Signaling Pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (6)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
5
4
6
92.5
smoking status measurement
2
2
2
68.1
body height
1
1
1
66.8
self reported educational attainment
2
3
3
64.4
neuroticism measurement
3
5
2
6.1
63.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
6
92.5
smoking status measurement
2
68.1
body height
1
66.8
self reported educational attainment
3
64.4
neuroticism measurement
2
6.1
63.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
F-box and leucine rich repeat protein 17 [Source:HGNC Symbol;Acc:HGNC:13615]
Mouse
MGI:1354704
50758
Pig
F-box and leucine rich repeat protein 17
100513341
Opossum
F-box and leucine rich repeat protein 17
100031220
Anole lizard
F-box and leucine rich repeat protein 17
100554365
Species
Name
OMA
EggNOG
Inparanoid
Macaque
F-box and leucine rich repeat protein 17 [Source:HGNC Symbol;Acc:HGNC:13615]
Mouse
Pig
F-box and leucine rich repeat protein 17
Opossum
F-box and leucine rich repeat protein 17
Anole lizard
F-box and leucine rich repeat protein 17
Publication Statistics
PubMed Score 6.20
PubMed score by year
PubTator Score 2.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title