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Tdark
FBXL16
F-box/LRR-repeat protein 16

Protein Summary
Description
Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Members of the F-box protein family, such as FBXL16, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324361
  • ENSP00000318674
  • ENSG00000127585
  • ENST00000397621
  • ENSP00000380746
  • ENST00000562563
  • ENSP00000455217

Symbol
  • C16orf22
  • FBL16
  • Fbl16
  • C16orf22
  • c380A1.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.65
small molecule perturbation
0.51
cell line
0.48
transcription factor perturbation
0.47
microRNA
0.46


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.41   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 120   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.41   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 120   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (329)
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.997941225
p_ni:  0.000012186
p_wrong:  0.002046589
Score:  0.973
Data Source:  BioPlex,STRINGDB
DAAM1
Tbio
Novelty:  0.02143008
p_int:  0.997660237
p_ni:  0.002339763
Score:  0.286
Data Source:  BioPlex,STRINGDB
UBB
Tbio
Novelty:  0.00661254
p_int:  0.98797235
p_ni:  0.01202765
Score:  0.921
Data Source:  BioPlex,STRINGDB
FBXL18
Tdark
Novelty:  0.33137957
p_int:  0.933691494
p_ni:  0.014208879
p_wrong:  0.052099627
Score:  0.964
Data Source:  BioPlex,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
Score:  0.969
Data Source:  STRINGDB
FBXL8
Tdark
Novelty:  0.84091737
Score:  0.946
Data Source:  STRINGDB
CUL3
Tbio
Novelty:  0.0028737
Score:  0.941
Data Source:  STRINGDB
KLHL25
Tbio
Novelty:  0.14475787
Score:  0.94
Data Source:  STRINGDB
KLHL21
Tbio
Novelty:  0.20694121
Score:  0.938
Data Source:  STRINGDB
RBX1
Tbio
Family:  Enzyme
Novelty:  0.00596986
Score:  0.938
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (20)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
2
9
10
91.7
BMI-adjusted waist circumference
1
7
7
82.8
cancer antigen 125 measurement
1
3
3
77.9
mean corpuscular volume
1
1
1
74.6
mean reticulocyte volume
1
1
1
72.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
10
91.7
BMI-adjusted waist circumference
7
82.8
cancer antigen 125 measurement
3
77.9
mean corpuscular volume
1
74.6
mean reticulocyte volume
1
72.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
F-box and leucine rich repeat protein 16
722364
Mouse
MGI:2448488
214931
Rat
RGD:1309127
494223
Dog
F-box and leucine rich repeat protein 16
VGNC:54023
490090
Horse
F-box and leucine rich repeat protein 16
VGNC:51130
100147621
Species
Name
OMA
EggNOG
Inparanoid
Macaque
F-box and leucine rich repeat protein 16
Mouse
Rat
Dog
F-box and leucine rich repeat protein 16
Horse
F-box and leucine rich repeat protein 16
Publication Statistics
PubMed Score 1.41
PubMed score by year
PubTator Score 0.50
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title