Tbio FBXL15 F-box/LRR-repeat protein 15

Protein Summary

Description

Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.

Uniprot Accession IDs

• Q9H469
• A1L4J8
• B1AKX8
• B1AKX9
• B1AKY0
• B1AKY1
• C9JWA4
• Q0D2Q3
• Q49AL7
• Q5JWA5

Gene Name

• FBXL15

Ensembl ID

• ENST00000224862
• ENSP00000224862
• ENSG00000107872

Symbol

• FBXO37
• JET
• PSD
• Fbl15
• FBXO37

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor binding site profile	0.85
transcription factor	0.7
kinase perturbation	0.66
small molecule perturbation	0.65
gene perturbation	0.62

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.11   (req: < 5)

Gene RIFs: 1   (req: <= 3)

Antibodies: 87   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.11   (req: >= 5)

Gene RIFs: 1   (req: > 3)

Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0