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Tbio
FBXL15
F-box/LRR-repeat protein 15

Protein Summary
Description
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SMURF1, thereby acting as a positive regulator of the BMP signaling pathway. Required for dorsal/ventral pattern formation and bone mass maintenance. Also mediates ubiquitination of SMURF2 and WWP2.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000224862
  • ENSP00000224862
  • ENSG00000107872

Symbol
  • FBXO37
  • JET
  • PSD
  • Fbl15
  • FBXO37
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.85
transcription factor
0.7
kinase perturbation
0.66
small molecule perturbation
0.65
gene perturbation
0.62


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.89   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 87   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.89   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 87   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (339)
CUL1
Tbio
Novelty:  0.00244476
p_int:  0.999656393
p_ni:  0.000343607
Score:  0.975
Data Source:  BioPlex,STRINGDB
SKP1
Tbio
Family:  Enzyme
Novelty:  0.00149739
p_int:  0.996471819
p_ni:  0.003527467
p_wrong:  7.15e-7
Score:  0.975
Data Source:  BioPlex,STRINGDB
ARIH1
Tbio
Family:  Enzyme
Novelty:  0.0258739
p_int:  0.832068645
p_ni:  0.167928729
p_wrong:  0.000002626
Score:  0.526
Data Source:  BioPlex,STRINGDB
FBXO9
Tbio
Novelty:  0.2145394
Score:  0.961
Data Source:  STRINGDB
CCNF
Tbio
Novelty:  0.01288697
Score:  0.959
Data Source:  STRINGDB
FBXW7
Tbio
Novelty:  0.00180856
Score:  0.959
Data Source:  STRINGDB
FBXO11
Tbio
Novelty:  0.02762674
Score:  0.957
Data Source:  STRINGDB
FBXW2
Tbio
Novelty:  0.01492058
Score:  0.953
Data Source:  STRINGDB
FBXL18
Tdark
Novelty:  0.33137957
Score:  0.952
Data Source:  STRINGDB
FBXW10
Tbio
Novelty:  0.11629778
Score:  0.949
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (24)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1
81.4
intelligence
3
3
2
6.5
72.1
cognitive function measurement
2
1
2
65.6
platelet crit
1
1
1
64.4
1
1
0
1.1
63.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1
81.4
intelligence
2
6.5
72.1
cognitive function measurement
2
65.6
platelet crit
1
64.4
0
1.1
63.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 15
VGNC:7226
745566
Mouse
MGI:1915681
68431
Rat
RGD:1306444
309453
Dog
F-box and leucine rich repeat protein 15
VGNC:52991
100855612
Horse
F-box and leucine rich repeat protein 15
VGNC:51505
100069952
Species
Name
OMA
EggNOG
Inparanoid
Chimp
F-box and leucine rich repeat protein 15
Mouse
Rat
Dog
F-box and leucine rich repeat protein 15
Horse
F-box and leucine rich repeat protein 15
Publication Statistics
PubMed Score 5.89
PubMed score by year
PubTator Score 29.75
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title