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Tbio
FBXL14
F-box/LRR-repeat protein 14

Protein Summary
Description
Substrate-recognition component of some SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin-protein ligase complexes. The SCF(FBXL14) complex acts by mediating ubiquitination and subsequent degradation of SNAI1. Members of the F-box protein family, such as FBXL14, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000339235
  • ENSP00000344855
  • ENSG00000171823

Symbol
  • FBL14
  • Fbl14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.97
transcription factor binding site profile
0.86
cell line
0.62
tissue sample
0.58
disease perturbation
0.56


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.11   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 103   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.11   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 103   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (327)
PPP1R21
Tdark
Family:  Enzyme
Novelty:  0.33099657
p_int:  0.999993218
p_ni:  0.000006781
p_wrong:  1e-9
Data Source:  BioPlex
TTC9C
Tdark
Novelty:  0.85949913
p_int:  0.999849473
p_ni:  0.000150527
Score:  0.187
Data Source:  BioPlex,STRINGDB
CRYZL1
Tbio
Family:  Enzyme
Novelty:  0.04435286
p_int:  0.999409532
p_ni:  0.000586488
p_wrong:  0.00000398
Score:  0.197
Data Source:  BioPlex,STRINGDB
CUL1
Tbio
Novelty:  0.00244476
p_int:  0.992953308
p_ni:  0.007046692
Score:  0.972
Data Source:  BioPlex,STRINGDB
SEC11C
Tdark
Family:  Enzyme
Novelty:  0.19577003
p_int:  0.992878368
p_ni:  0.00685325
p_wrong:  0.000268382
Score:  0.204
Data Source:  BioPlex,STRINGDB
TLE1
Tbio
Novelty:  0.00594261
p_int:  0.987828639
p_ni:  0.000001375
p_wrong:  0.012169986
Data Source:  BioPlex
SUGT1
Tbio
Novelty:  0.1042721
p_int:  0.986412297
p_ni:  0.013587703
Score:  0.179
Data Source:  BioPlex,STRINGDB
AAGAB
Tbio
Novelty:  0.0479209
p_int:  0.98586097
p_ni:  0.014139029
Data Source:  BioPlex
ITPR1
Tchem
Family:  IC
Novelty:  0.00111834
p_int:  0.971097466
p_ni:  0.028902534
Score:  0.225
Data Source:  BioPlex,STRINGDB
COPS2
Tbio
Novelty:  0.03509351
p_int:  0.963564825
p_ni:  0.036435175
Score:  0.953
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (7)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing: Ubiquitination & Proteasome degradation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Immune System
Reactome
Metabolism of proteins
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing: Ubiquitination & Proteasome degradation
Class I MHC mediated antigen processing & presentation
Immune System
Metabolism of proteins
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
7
15
98.4
bone density
2
2
2
57
red blood cell distribution width
1
1
1
12.1
mean corpuscular volume
1
1
1
3.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
15
98.4
bone density
2
57
red blood cell distribution width
1
12.1
mean corpuscular volume
1
3.9
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
F-box and leucine rich repeat protein 14
721679
Mouse
MGI:2141676
101358
Dog
F-box and leucine rich repeat protein 14
486755
Horse
F-box and leucine rich repeat protein 14
VGNC:17937
102148197
Cow
F-box and leucine rich repeat protein 14
VGNC:28890
531211
Species
Name
OMA
EggNOG
Inparanoid
Macaque
F-box and leucine rich repeat protein 14
Mouse
Dog
F-box and leucine rich repeat protein 14
Horse
F-box and leucine rich repeat protein 14
Cow
F-box and leucine rich repeat protein 14
Publication Statistics
PubMed Score 4.11
PubMed score by year
PubTator Score 3.83
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title