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Tbio
FBRS
Probable fibrosin-1

Protein Summary
Description
Fibrosin is a lymphokine secreted by activated lymphocytes that induces fibroblast proliferation (Prakash and Robbins, 1998 [PubMed 9809749]).[supplied by OMIM, Mar 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287468
  • ENSP00000287468
  • ENSG00000156860

Symbol
  • FBS
  • FBS1
  • FBS
  • FBS1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
tissue sample
0.7
disease perturbation
0.68
cell line
0.63
small molecule perturbation
0.62
tissue
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.25   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 63   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8.25   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 63   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (26)
CSNK2A2
Tchem
Family:  Kinase
Novelty:  0.00231447
p_int:  0.999999878
p_ni:  1.22e-7
Score:  0.71
Data Source:  BioPlex,STRINGDB
PCGF5
Tdark
Novelty:  0.11370936
p_int:  0.999999683
p_ni:  3.09e-7
p_wrong:  9e-9
Score:  0.914
Data Source:  BioPlex,STRINGDB
CSNK2B
Tbio
Family:  Kinase
Novelty:  0.00152367
p_int:  0.99999936
p_ni:  6.24e-7
p_wrong:  1.5e-8
Data Source:  BioPlex
RYBP
Tbio
Novelty:  0.01140945
p_int:  0.999999351
p_ni:  6.49e-7
Score:  0.84
Data Source:  BioPlex,STRINGDB
YAF2
Tbio
Novelty:  0.10772286
p_int:  0.999998251
p_ni:  0.000001749
Score:  0.725
Data Source:  BioPlex,STRINGDB
DCAF7
Tbio
Novelty:  0.02609518
p_int:  0.999998101
p_ni:  0.000001899
Score:  0.613
Data Source:  BioPlex,STRINGDB
PCGF6
Tbio
Novelty:  0.07032909
p_int:  0.999996713
p_ni:  0.000003287
Score:  0.714
Data Source:  BioPlex,STRINGDB
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.999917716
p_ni:  0.000082146
p_wrong:  1.38e-7
Data Source:  BioPlex
FANCD2OS
Tdark
Novelty:  9.51798561
p_int:  0.999832952
p_ni:  0.000167047
p_wrong:  1e-9
Data Source:  BioPlex
PRPF31
Tbio
Novelty:  0.0105753
p_int:  0.996896104
p_ni:  0.003103895
p_wrong:  1e-9
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (3)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Disease Associations (null)
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
67.1
heel bone mineral density
1
1
1
45.2
eosinophil count
1
1
1
42.3
self reported educational attainment
1
1
1
29
1
1
0
1.1
12.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
67.1
heel bone mineral density
1
45.2
eosinophil count
1
42.3
self reported educational attainment
1
29
0
1.1
12.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibrosin
VGNC:5766
741461
Mouse
MGI:104648
14123
Dog
fibrosin
VGNC:40758
607426
Anole lizard
fibrosin
100558374
Xenopus
fibrosin
XB-GENE-6469614
100145044
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibrosin
Mouse
Dog
fibrosin
Anole lizard
fibrosin
Xenopus
fibrosin
Publication Statistics
PubMed Score 8.25
PubMed score by year
PubTator Score 30.18
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title