Protein Summary
Fibrillin-2: Fibrillins are structural components of 10-12 nm extracellular calcium-binding microfibrils, which occur either in association with elastin or in elastin-free bundles. Fibrillin-2-containing microfibrils regulate the early process of elastic fiber assembly. Regulates osteoblast maturation by controlling TGF-beta bioavailability and calibrating TGF-beta and BMP levels, respectively. The protein encoded by this gene is a component of connective tissue microfibrils and may be involved in elastic fiber assembly. Mutations in this gene cause congenital contractural arachnodactyly. [provided by RefSeq, Jul 2008]
- ENST00000262464
- ENSP00000262464
- ENSG00000138829
- ENST00000508053
- ENSP00000424571
- CCA
- DA9
- EOMD
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.99 | ||
PubMedID | 0.97 | ||
gene perturbation | 0.91 | ||
trait | 0.86 | ||
microRNA | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 192.87 (req: < 5)
Gene RIFs: 34 (req: <= 3)
Antibodies: 156 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 192.87 (req: >= 5)
Gene RIFs: 34 (req: > 3)
Antibodies: 156 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (91)
MFAP5
Novelty: 0.01839035
p_int: 0.973466113
p_ni: 0.026533887
Score: 0.966
Data Source: BioPlex,Reactome,STRINGDB
KLKB1
Family: Enzyme
Novelty: 0.00109438
p_int: 0.968836973
p_ni: 0.031163027
Data Source: BioPlex
FOXD4L6
Family: TF
Novelty: 9.78461538
p_int: 0.962406747
p_ni: 0.037593253
Score: 0.189
Data Source: BioPlex,STRINGDB
ADAMTSL1
Novelty: 0.08853044
p_int: 0.884442954
p_ni: 0.115557046
Score: 0.491
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Elastic fibre formation | ||||
Reactome | Extracellular matrix organization | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Elastic fibre formation | ||||
Extracellular matrix organization | ||||
Viral Interactions (0)
Gene Ontology Terms (15)
Functions (3)
Components (4)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred by Curator (IC) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (18)
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 3 | 6 | 7 | 94.4 | |||||
testosterone measurement | 3 | 3 | 3 | 81.4 | |||||
appendicular lean mass | 1 | 2 | 2 | 72.4 | |||||
BMI-adjusted hip circumference | 1 | 4 | 4 | 72 | |||||
Varicose veins | 1 | 1 | 1 | 71.9 | |||||
Items per page:
1 – 5 of 18
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 7 | 94.4 | |||||
testosterone measurement | 3 | 81.4 | |||||
appendicular lean mass | 2 | 72.4 | |||||
BMI-adjusted hip circumference | 4 | 72 | |||||
Varicose veins | 1 | 71.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (6)
1 – 5 of 6
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:95490 | 14119 | ||||||
Rat | RGD:620910 | 689008 | ||||||
Dog | fibrillin 2 | VGNC:40755 | 481491 | |||||
Horse | fibrillin 2 | VGNC:17934 | 100073031 | |||||
Chicken | fibrillin 2 | CGNC:49083 | 374203 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | fibrillin 2 | |||||
Horse | fibrillin 2 | |||||
Chicken | fibrillin 2 | |||||
Publication Statistics
PubMed Score 192.87
PubMed score by year
PubTator Score 222.81
PubTator score by year
Related Publications
Text Mined References (64)
GeneRif Annotations (34)
Items per page:
0 of 0
PMID | Year | Title |
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