Protein Summary
Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108). This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000295760
- ENSP00000295760
- ENSG00000163520
- ENST00000404922
- ENSP00000384169
- ENST00000492059
- ENSP00000420042
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 0.97 | ||
gene perturbation | 0.91 | ||
tissue sample | 0.69 | ||
virus | 0.66 | ||
disease perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 80.6 (req: < 5)
Gene RIFs: 8 (req: <= 3)
Antibodies: 244 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 80.6 (req: >= 5)
Gene RIFs: 8 (req: > 3)
Antibodies: 244 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (90)
EFEMP1
Novelty: 0.00574779
p_int: 0.999996844
p_ni: 0.000003142
p_wrong: 1.3e-8
Score: 0.922
Data Source: BioPlex,STRINGDB
ZNF709
Family: TF
Novelty: 2.94299911
p_int: 0.99996653
p_ni: 0.000018106
p_wrong: 0.000015363
Data Source: BioPlex
ZNF628
Family: TF
Novelty: 0.50407457
p_int: 0.999946984
p_ni: 0.000032723
p_wrong: 0.000020293
Data Source: BioPlex
CXCL5
Novelty: 0.00286795
p_int: 0.999931489
p_ni: 0.000068466
p_wrong: 4.5e-8
Data Source: BioPlex
ZNF627
Family: TF
Novelty: 0.34605017
p_int: 0.99993122
p_ni: 0.000064042
p_wrong: 0.000004738
Data Source: BioPlex
ZNF77
Family: TF
Novelty: 0.00135172
p_int: 0.99987679
p_ni: 0.000010046
p_wrong: 0.000113165
Data Source: BioPlex
ZNF101
Family: TF
Novelty: 0.27004566
p_int: 0.999192785
p_ni: 0.000796659
p_wrong: 0.000010556
Data Source: BioPlex
ZNF358
Family: TF
Novelty: 0.77495044
p_int: 0.999093786
p_ni: 0.000906111
p_wrong: 1.02e-7
Data Source: BioPlex
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Elastic fibre formation | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Molecules associated with elastic fibres | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Elastic fibre formation | ||||
Extracellular matrix organization | ||||
Molecules associated with elastic fibres | ||||
Viral Interactions (0)
Gene Ontology Terms (10)
Functions (4)
Components (4)
Processes (2)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | ProtInc | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 3 | 6 | 6 | 74 | |||||
visceral adipose tissue measurement | 1 | 1 | 1 | 67.4 | |||||
hematocrit | 2 | 2 | 2 | 66.6 | |||||
hemoglobin measurement | 1 | 1 | 1 | 46.9 | |||||
appendicular lean mass | 1 | 1 | 1 | 30.2 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted hip circumference | 6 | 74 | |||||
visceral adipose tissue measurement | 1 | 67.4 | |||||
hematocrit | 2 | 66.6 | |||||
hemoglobin measurement | 1 | 46.9 | |||||
appendicular lean mass | 1 | 30.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | fibulin 2 | VGNC:1815 | 460192 | |||||
Macaque | fibulin 2 | 100429735 | ||||||
Mouse | MGI:95488 | 14115 | ||||||
Rat | RGD:628685 | 282583 | ||||||
Dog | fibulin 2 | VGNC:40751 | 484634 | |||||
Publication Statistics
PubMed Score 80.60
PubMed score by year
PubTator Score 46.77
PubTator score by year
Related Publications
Text Mined References (42)
GeneRif Annotations (8)
Items per page:
0 of 0
PMID | Year | Title |
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