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Tbio
FBLN2
Fibulin-2

Protein Summary
Description
Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108). This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295760
  • ENSP00000295760
  • ENSG00000163520
  • ENST00000404922
  • ENSP00000384169
  • ENST00000492059
  • ENSP00000420042
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
gene perturbation
0.91
tissue sample
0.69
virus
0.66
disease perturbation
0.62


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.6   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 244   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 80.6   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 244   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (90)
ZNF664
Tdark
Family:  TF
Novelty:  0.25879878
p_int:  0.999997485
p_ni:  0.000002514
Data Source:  BioPlex
EFEMP1
Tbio
Novelty:  0.00574779
p_int:  0.999996844
p_ni:  0.000003142
p_wrong:  1.3e-8
Score:  0.922
Data Source:  BioPlex,STRINGDB
ZNF709
Tdark
Family:  TF
Novelty:  2.94299911
p_int:  0.99996653
p_ni:  0.000018106
p_wrong:  0.000015363
Data Source:  BioPlex
ZNF628
Tdark
Family:  TF
Novelty:  0.50407457
p_int:  0.999946984
p_ni:  0.000032723
p_wrong:  0.000020293
Data Source:  BioPlex
CXCL5
Tbio
Novelty:  0.00286795
p_int:  0.999931489
p_ni:  0.000068466
p_wrong:  4.5e-8
Data Source:  BioPlex
ZNF627
Tdark
Family:  TF
Novelty:  0.34605017
p_int:  0.99993122
p_ni:  0.000064042
p_wrong:  0.000004738
Data Source:  BioPlex
ZNF77
Tbio
Family:  TF
Novelty:  0.00135172
p_int:  0.99987679
p_ni:  0.000010046
p_wrong:  0.000113165
Data Source:  BioPlex
ZNF101
Tdark
Family:  TF
Novelty:  0.27004566
p_int:  0.999192785
p_ni:  0.000796659
p_wrong:  0.000010556
Data Source:  BioPlex
ZNF358
Tdark
Family:  TF
Novelty:  0.77495044
p_int:  0.999093786
p_ni:  0.000906111
p_wrong:  1.02e-7
Data Source:  BioPlex
ZNF696
Tdark
Family:  TF
Novelty:  3.49300122
p_int:  0.997623536
p_ni:  0.002376464
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Elastic fibre formation (R-HSA-1566948)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Elastic fibre formation
Reactome
Extracellular matrix organization
Reactome
Molecules associated with elastic fibres
Name
Explore in Pharos
Explore in Source
Elastic fibre formation
Extracellular matrix organization
Molecules associated with elastic fibres
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
3
6
6
74
visceral adipose tissue measurement
1
1
1
67.4
hematocrit
2
2
2
66.6
hemoglobin measurement
1
1
1
46.9
appendicular lean mass
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted hip circumference
6
74
visceral adipose tissue measurement
1
67.4
hematocrit
2
66.6
hemoglobin measurement
1
46.9
appendicular lean mass
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibulin 2
VGNC:1815
460192
Macaque
fibulin 2
100429735
Mouse
MGI:95488
14115
Rat
RGD:628685
282583
Dog
fibulin 2
VGNC:40751
484634
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibulin 2
Macaque
fibulin 2
Mouse
Rat
Dog
fibulin 2
Publication Statistics
PubMed Score 80.60
PubMed score by year
PubTator Score 46.77
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title