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Tbio
FBF1
Fas-binding factor 1

Protein Summary
Description
Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000586717
  • ENSP00000465132
  • ENSG00000188878
  • ENST00000636174
  • ENSP00000490726

Symbol
  • ALB
  • KIAA1863
  • Alb
  • FBF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor
0.77
transcription factor binding site profile
0.74
cell line
0.69
gene perturbation
0.68


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.43   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 32   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.43   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 32   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (124)
HIF1AN
Tbio
Novelty:  0.00861018
p_int:  0.999998906
p_ni:  0.000001094
Score:  0.235
Data Source:  BioPlex,STRINGDB
SCLT1
Tbio
Novelty:  0.10969171
Score:  0.985
Data Source:  STRINGDB
CEP83
Tdark
Novelty:  0.15704554
Score:  0.981
Data Source:  STRINGDB
CEP164
Tbio
Novelty:  0.04775724
Score:  0.977
Data Source:  STRINGDB
CEP89
Tbio
Novelty:  0.17461805
Score:  0.976
Data Source:  STRINGDB
TTBK2
Tbio
Family:  Kinase
Novelty:  0.03262289
Score:  0.961
Data Source:  STRINGDB
CCP110
Tbio
Novelty:  0.02399511
Score:  0.956
Data Source:  STRINGDB
C2CD3
Tbio
Novelty:  0.10910688
Score:  0.955
Data Source:  STRINGDB
ODF2
Tbio
Novelty:  0.03203587
Score:  0.953
Data Source:  STRINGDB
RAB3IP
Tbio
Novelty:  0.04046982
Score:  0.944
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (4)
Anchoring of the basal body to the plasma membrane (R-HSA-5620912)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Anchoring of the basal body to the plasma membrane
Reactome
Cilium Assembly
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Anchoring of the basal body to the plasma membrane
Cilium Assembly
Organelle biogenesis and maintenance
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (19)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
9
7
10
12.5
99.3
low density lipoprotein cholesterol measurement
1
1
1
82
mean platelet volume
2
2
2
74.5
brain volume measurement
1
1
1
68.3
body mass index
3
3
3
63.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
white matter hyperintensity measurement
10
12.5
99.3
low density lipoprotein cholesterol measurement
1
82
mean platelet volume
2
74.5
brain volume measurement
1
68.3
body mass index
3
63.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fas binding factor 1
VGNC:51659
454894
Macaque
Fas binding factor 1
708559
Mouse
MGI:1922033
217335
Rat
RGD:1310662
287836
Dog
Fas binding factor 1
VGNC:51955
483321
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fas binding factor 1
Macaque
Fas binding factor 1
Mouse
Rat
Dog
Fas binding factor 1
Publication Statistics
PubMed Score 27.43
PubMed score by year
PubTator Score 5.28
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title