Protein Summary
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
- ENST00000441802
- ENSP00000406229
- ENSG00000083857
- CDHF7
- FAT
- FAT
- ME5
- CDHF7
- CDHR8
- hFat1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
transcription factor perturbation | 0.96 | ||
cellular component | 0.72 | ||
disease | 0.61 | ||
cell line | 0.59 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 369.13 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 148 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 369.13 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 148 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (94)
IFNE
Novelty: 0.01597003
p_int: 0.889664611
p_ni: 0.110335389
Score: 0.169
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (10)
PathwayCommons (2)
WikiPathways (8)
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
PathwayCommons: panther | Cadherin signaling pathway | ||||
PathwayCommons: panther | Wnt signaling pathway | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cadherin signaling pathway | ||||
Wnt signaling pathway | ||||
Viral Interactions (0)
Gene Ontology Terms (22)
Functions (1)
Components (10)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 2 | 2 | 2 | 60.8 | |||||
heel bone mineral density | 2 | 2 | 2 | 57.1 | |||||
reticulocyte count | 1 | 1 | 1 | 42.3 | |||||
Calcium channel blocker use measurement | 1 | 1 | 1 | 17.8 | |||||
urinary albumin to creatinine ratio | 1 | 1 | 1 | 3.4 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 2 | 60.8 | |||||
heel bone mineral density | 2 | 57.1 | |||||
reticulocyte count | 1 | 42.3 | |||||
Calcium channel blocker use measurement | 1 | 17.8 | |||||
urinary albumin to creatinine ratio | 1 | 3.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (11)
1 – 5 of 11
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | FAT atypical cadherin 1 | VGNC:597 | 461671 | |||||
Mouse | MGI:109168 | 14107 | ||||||
Rat | RGD:621254 | 83720 | ||||||
Dog | FAT atypical cadherin 1 | VGNC:40742 | 475621 | |||||
Horse | FAT atypical cadherin 1 | VGNC:17924 | 100050525 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | FAT atypical cadherin 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | FAT atypical cadherin 1 | |||||
Horse | FAT atypical cadherin 1 | |||||
Publication Statistics
PubMed Score 369.13
PubMed score by year
PubTator Score 667.10
PubTator score by year
Related Publications
Text Mined References (58)
GeneRif Annotations (42)
Items per page:
0 of 0
PMID | Year | Title |
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