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Tbio
FAT1
Protocadherin Fat 1

Protein Summary
Description
Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact. This gene is an ortholog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has five epidermal growth factor (EGF)-like repeats and one laminin A-G domain. This gene is expressed at high levels in a number of fetal epithelia. Its product probably functions as an adhesion molecule and/or signaling receptor, and is likely to be important in developmental processes and cell communication. Transcript variants derived from alternative splicing and/or alternative promoter usage exist, but they have not been fully described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000441802
  • ENSP00000406229
  • ENSG00000083857

Symbol
  • CDHF7
  • FAT
  • FAT
  • ME5
  • CDHF7
  • CDHR8
  • hFat1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
transcription factor perturbation
0.96
cellular component
0.72
disease
0.61
cell line
0.59


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 369.13   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 148   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 369.13   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 148   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (94)
CD160
Tbio
Novelty:  0.01511748
p_int:  0.997495992
p_ni:  0.002504008
Data Source:  BioPlex
CMA1
Tchem
Family:  Enzyme
Novelty:  0.00091144
p_int:  0.98300552
p_ni:  0.01699448
Data Source:  BioPlex
PSG8
Tdark
Novelty:  0.1446257
p_int:  0.981629728
p_ni:  0.018370272
Data Source:  BioPlex
HYOU1
Tbio
Novelty:  0.00833649
p_int:  0.970915278
p_ni:  0.029084722
Data Source:  BioPlex
XAGE1A
Tbio
Novelty:  0.04421526
p_int:  0.960395981
p_ni:  0.039604019
Data Source:  BioPlex
LAG3
Tbio
Novelty:  0.00187736
p_int:  0.942325739
p_ni:  0.057674261
Data Source:  BioPlex
PDGFB
Tbio
Novelty:  0.00080876
p_int:  0.930703804
p_ni:  0.069296196
Data Source:  BioPlex
SLAMF1
Tbio
Novelty:  0.00112892
p_int:  0.928151535
p_ni:  0.071848465
Data Source:  BioPlex
GML
Tdark
Novelty:  0.04982168
p_int:  0.905760605
p_ni:  0.094239394
Data Source:  BioPlex
IFNE
Tbio
Novelty:  0.01597003
p_int:  0.889664611
p_ni:  0.110335389
Score:  0.169
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Find Similar Targets
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: panther
Cadherin signaling pathway
PathwayCommons: panther
Wnt signaling pathway
Name
Explore in Pharos
Explore in Source
Cadherin signaling pathway
Wnt signaling pathway
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (22)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
2
2
60.8
heel bone mineral density
2
2
2
57.1
reticulocyte count
1
1
1
42.3
Calcium channel blocker use measurement
1
1
1
17.8
urinary albumin to creatinine ratio
1
1
1
3.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
2
60.8
heel bone mineral density
2
57.1
reticulocyte count
1
42.3
Calcium channel blocker use measurement
1
17.8
urinary albumin to creatinine ratio
1
3.4
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FAT atypical cadherin 1
VGNC:597
461671
Mouse
MGI:109168
14107
Rat
RGD:621254
83720
Dog
FAT atypical cadherin 1
VGNC:40742
475621
Horse
FAT atypical cadherin 1
VGNC:17924
100050525
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FAT atypical cadherin 1
Mouse
Rat
Dog
FAT atypical cadherin 1
Horse
FAT atypical cadherin 1
Publication Statistics
PubMed Score 369.13
PubMed score by year
PubTator Score 667.10
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title