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Tdark
FASTKD5
FAST kinase domain-containing protein 5, mitochondrial

Protein Summary
Description
Plays an important role in the processing of non-canonical mitochondrial mRNA precursors (PubMed:25683715).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380266
  • ENSP00000369618
  • ENSG00000215251

Symbol
  • KIAA1792
  • dJ1187M17.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.94
kinase perturbation
0.91
disease perturbation
0.87
tissue sample
0.72
transcription factor binding site profile
0.61


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.04   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 77   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.04   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 77   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (35)
MAPK4
Tbio
Family:  Kinase
Novelty:  0.0223868
p_int:  0.978759627
p_ni:  0.021240373
Score:  0.29
Data Source:  BioPlex,STRINGDB
NPY2R
Tchem
Family:  GPCR
Novelty:  0.01177255
p_int:  0.753369725
p_ni:  0.246630275
Score:  0.237
Data Source:  BioPlex,STRINGDB
FASTKD2
Tbio
Family:  Enzyme
Novelty:  0.12614412
Score:  0.685
Data Source:  STRINGDB
PTCD2
Tdark
Novelty:  0.23529342
Score:  0.599
Data Source:  STRINGDB
RPUSD3
Tdark
Family:  Enzyme
Novelty:  1.00226099
Score:  0.582
Data Source:  STRINGDB
DDX28
Tbio
Family:  Enzyme
Novelty:  0.16760542
Score:  0.578
Data Source:  STRINGDB
OXA1L
Tbio
Novelty:  0.00235517
Score:  0.571
Data Source:  STRINGDB
TFAM
Tbio
Family:  TF
Novelty:  0.00131608
Score:  0.567
Data Source:  STRINGDB
FASTK
Tbio
Family:  Kinase
Novelty:  0.01935506
Score:  0.563
Data Source:  STRINGDB
GRSF1
Tbio
Novelty:  0.05905648
Score:  0.554
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (9)
Find Similar Targets
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
2
0
14.8
81.4
serum gamma-glutamyl transferase measurement
2
2
2
78.7
household income
2
3
4
55.1
reticulocyte measurement
1
1
1
36.5
risk-taking behaviour
1
1
1
30.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
14.8
81.4
serum gamma-glutamyl transferase measurement
2
78.7
household income
4
55.1
reticulocyte measurement
1
36.5
risk-taking behaviour
1
30.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
FAST kinase domains 5
100498658
Mouse
MGI:2139469
380601
Dog
FAST kinase domains 5
VGNC:40741
106557474
Horse
FAST kinase domains 5
VGNC:17923
100052656
Xenopus
FAST kinase domains 5 [Source:Xenbase;Acc:XB-GENE-6258297]
Species
Name
OMA
EggNOG
Inparanoid
Macaque
FAST kinase domains 5
Mouse
Dog
FAST kinase domains 5
Horse
FAST kinase domains 5
Xenopus
FAST kinase domains 5 [Source:Xenbase;Acc:XB-GENE-6258297]
Publication Statistics
PubMed Score 1.04
PubMed score by year
PubTator Score 0.85
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title