You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FASTK
Fas-activated serine/threonine kinase

Protein Summary
Description
Phosphorylates the splicing regulator TIA1, thereby promoting the inclusion of FAS exon 6, which leads to an mRNA encoding a pro-apoptotic form of the receptor. Isoform 4: Required for the biogenesis of some mitochondrial-encoded mRNAs, specifically stabilizes ND6 (NADH dehydrogenase complex subunit 6) mRNA, and regulates its levels. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase was shown to be activated rapidly during Fas-mediated apoptosis in Jurkat cells. In response to Fas receptor ligation, it phosphorylates TIA1, an apoptosis-promoting nuclear RNA-binding protein. The encoded protein is a strong inducer of lymphocyte apoptosis. Two transcript variants encoding different isoforms have been found for this gene. Other variants exist, but their full-length natures have not yet been determined. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000297532
  • ENSP00000297532
  • ENSG00000164896
  • ENST00000353841
  • ENSP00000324817
  • ENST00000482571
  • ENSP00000418516

Symbol
  • FAST
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.93
virus perturbation
0.85
kinase perturbation
0.81
transcription factor binding site profile
0.65
cell line
0.61


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.99   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.99   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (27)
LARP4B
Tbio
Novelty:  0.11363794
p_int:  0.987871588
p_ni:  1.97e-7
p_wrong:  0.012128215
Data Source:  BioPlex
TIA1
Tbio
Novelty:  0.00264338
Score:  0.875
Data Source:  STRINGDB
FASTKD2
Tbio
Family:  Enzyme
Novelty:  0.12614412
Score:  0.802
Data Source:  STRINGDB
FASTKD1
Tbio
Family:  Enzyme
Novelty:  0.64864074
Score:  0.772
Data Source:  STRINGDB
TIAL1
Tbio
Novelty:  0.01126806
Score:  0.64
Data Source:  STRINGDB
GRSF1
Tbio
Novelty:  0.05905648
Score:  0.601
Data Source:  STRINGDB
NME3
Tbio
Family:  Kinase
Novelty:  0.05947052
Score:  0.567
Data Source:  STRINGDB
FASTKD5
Tdark
Family:  Enzyme
Novelty:  0.67574493
Score:  0.563
Data Source:  STRINGDB
SIVA1
Tbio
Novelty:  0.03872239
Score:  0.552
Data Source:  STRINGDB
RPUSD3
Tdark
Family:  Enzyme
Novelty:  1.00226099
Score:  0.52
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (32)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
3
5
5
93.9
diastolic blood pressure
3
2
3
90.6
5
1
3
1.1
89.3
heel bone mineral density
2
1
2
76.6
glomerular filtration rate
2
1
2
76.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
5
93.9
diastolic blood pressure
3
90.6
3
1.1
89.3
heel bone mineral density
2
76.6
glomerular filtration rate
2
76.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
Fas activated serine/threonine kinase
VGNC:7380
472626
Macaque
Fas activated serine/threonine kinase
714020
Mouse
MGI:1913837
66587
Rat
RGD:1311601
296741
Dog
Fas activated serine/threonine kinase
VGNC:40737
482802
Species
Name
OMA
EggNOG
Inparanoid
Chimp
Fas activated serine/threonine kinase
Macaque
Fas activated serine/threonine kinase
Mouse
Rat
Dog
Fas activated serine/threonine kinase
Publication Statistics
PubMed Score 95.99
PubMed score by year
PubTator Score 8.26
PubTator score by year
Patents
Patents by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title