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Tbio
FAS
Tumor necrosis factor receptor superfamily member 6

Protein Summary
Description
Receptor for TNFSF6/FASLG. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. FAS-mediated apoptosis may have a role in the induction of peripheral tolerance, in the antigen-stimulated suicide of mature T-cells, or both. The secreted isoforms 2 to 6 block apoptosis (in vitro). The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355279
  • ENSP00000347426
  • ENSG00000026103
  • ENST00000355740
  • ENSP00000347979
  • ENST00000357339
  • ENSP00000349896
  • ENST00000479522
  • ENSP00000424113
  • ENST00000484444
  • ENSP00000420975
  • ENST00000488877
  • ENSP00000425159
  • ENST00000492756
  • ENSP00000422453
  • ENST00000494410
  • ENSP00000423755

Symbol
  • APT1
  • FAS1
  • TNFRSF6
  • APT1
  • CD95
  • FAS1
  • APO-1
  • FASTM
  • ALPS1A
  • TNFRSF6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
biological process
0.98
virus perturbation
0.94
gene perturbation
0.93
hub protein
0.92


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2244.17   (req: < 5)
Gene RIFs: 891   (req: <= 3)
Antibodies: 2611   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2244.17   (req: >= 5)
Gene RIFs: 891   (req: > 3)
Antibodies: 2611   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0