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Tchem
FARSB
Phenylalanine--tRNA ligase beta subunit

Protein Summary
Description
This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000281828
  • ENSP00000281828
  • ENSG00000116120

Symbol
  • FARSLB
  • FRSB
  • FRSB
  • PheHB
  • PheRS
  • FARSLB
  • RILDBC
  • HSPC173
  • NEDBLLA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.95
molecular function
0.95
small molecule perturbation
0.88
histone modification site profile
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.69   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 258   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 11.69   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 258   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (168)
FARSA
Tbio
Family:  Enzyme
Novelty:  0.03623677
p_int:  0.999929149
p_ni:  0.000070851
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
ZBTB9
Tdark
Novelty:  0.95590016
p_int:  0.999661471
p_ni:  0.000157599
p_wrong:  0.000180929
Data Source:  BioPlex
PITX1
Tbio
Family:  TF
Novelty:  0.00499796
p_int:  0.999347589
p_ni:  1e-9
p_wrong:  0.000652411
Data Source:  BioPlex
ARSF
Tbio
Family:  Enzyme
Novelty:  0.13109678
p_int:  0.999022931
p_ni:  0.000977067
p_wrong:  2e-9
Data Source:  BioPlex
BRK1
Tbio
Novelty:  0.02289534
p_int:  0.993609235
p_ni:  0.006388822
p_wrong:  0.000001943
Data Source:  BioPlex
GTF2E2
Tbio
Novelty:  0.18033153
p_int:  0.986490953
p_ni:  0.013509047
Data Source:  BioPlex
GHRL
Tbio
Novelty:  0.00017827
p_int:  0.9684667
p_ni:  0.000231266
p_wrong:  0.031302034
Data Source:  BioPlex
APBA3
Tbio
Novelty:  0.05059532
p_int:  0.950763209
p_ni:  0.049236791
Data Source:  BioPlex
HSBP1
Tbio
Novelty:  0.09422832
p_int:  0.938377239
p_ni:  0.061622757
p_wrong:  4e-9
Data Source:  BioPlex
CADM4
Tbio
Novelty:  0.05034541
p_int:  0.935530253
p_ni:  0.03738418
p_wrong:  0.027085567
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Cytosolic tRNA aminoacylation (R-HSA-379716)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytosolic tRNA aminoacylation
Reactome
Metabolism of proteins
Reactome
Translation
Reactome
tRNA Aminoacylation
Name
Explore in Pharos
Explore in Source
Cytosolic tRNA aminoacylation
Metabolism of proteins
Translation
tRNA Aminoacylation
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
facial morphology measurement
1
1
1
21.5
chin morphology measurement
1
1
0
1.2
21.2
sex hormone-binding globulin measurement
2
1
2
5.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
facial morphology measurement
1
21.5
chin morphology measurement
0
1.2
21.2
sex hormone-binding globulin measurement
2
5.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phenylalanyl-tRNA synthetase subunit beta
VGNC:428
470661
Macaque
phenylalanyl-tRNA synthetase beta subunit
705557
Mouse
MGI:1346035
23874
Rat
RGD:1303210
301544
Dog
phenylalanyl-tRNA synthetase beta subunit
478926
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phenylalanyl-tRNA synthetase subunit beta
Macaque
phenylalanyl-tRNA synthetase beta subunit
Mouse
Rat
Dog
phenylalanyl-tRNA synthetase beta subunit
Publication Statistics
PubMed Score 11.69
PubMed score by year
PubTator Score 26.29
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title