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Tbio
FANK1
Fibronectin type 3 and ankyrin repeat domains protein 1

Protein Summary
Description
Through the activation of JUN and AP-1-mediated transcription, may regulate apoptosis.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368693
  • ENSP00000357682
  • ENSG00000203780

Symbol
  • HSD13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.75
tissue sample
0.62
trait
0.61
protein domain
0.58
gene perturbation
0.57


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.54   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 89   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.54   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 89   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (41)
ATG4B
Tchem
Family:  Enzyme
Novelty:  0.0088416
p_int:  0.999999099
p_ni:  3.56e-7
p_wrong:  5.45e-7
Score:  0.555
Data Source:  BioPlex,STRINGDB
A4GNT
Tbio
Family:  Enzyme
Novelty:  0.08971876
p_int:  0.999980804
p_ni:  0.00000596
p_wrong:  0.000013236
Score:  0.237
Data Source:  BioPlex,STRINGDB
UBXN2B
Tbio
Novelty:  0.67291382
p_int:  0.999894
p_ni:  0.000105999
p_wrong:  1e-9
Score:  0.226
Data Source:  BioPlex,STRINGDB
VCAM1
Tchem
Novelty:  0.00022504
p_int:  0.994840579
p_ni:  0.001155938
p_wrong:  0.004003483
Score:  0.19
Data Source:  BioPlex,STRINGDB
COPS5
Tchem
Novelty:  0.00406225
Score:  0.748
Data Source:  STRINGDB
RYBP
Tbio
Novelty:  0.01140945
Score:  0.736
Data Source:  STRINGDB
SPATA4
Tbio
Novelty:  0.11011458
Score:  0.735
Data Source:  STRINGDB
CYB5R2
Tbio
Family:  Enzyme
Novelty:  0.11426461
Score:  0.71
Data Source:  STRINGDB
CFAP70
Tdark
Novelty:  1.0349863
Score:  0.665
Data Source:  STRINGDB
LRRIQ1
Tdark
Novelty:  1.8251367
Score:  0.642
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (10)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
1
1
70.2
red blood cell distribution width
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean corpuscular hemoglobin concentration
1
70.2
red blood cell distribution width
1
44.2
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fibronectin type III and ankyrin repeat domains 1
VGNC:10351
100612799
Macaque
fibronectin type III and ankyrin repeat domains 1
696281
Mouse
MGI:1914180
66930
Rat
RGD:1304756
309071
Dog
fibronectin type III and ankyrin repeat domains 1
VGNC:40726
611459
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fibronectin type III and ankyrin repeat domains 1
Macaque
fibronectin type III and ankyrin repeat domains 1
Mouse
Rat
Dog
fibronectin type III and ankyrin repeat domains 1
Publication Statistics
PubMed Score 12.54
PubMed score by year
PubTator Score 5.89
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title